TY - JOUR
T1 - Separation of a diblock-triblock copolymer mixture by phase fluctuation chromatography
AU - Fujiwara, T.
AU - Kimura, Y.
AU - Teraoka, I.
N1 - Funding Information:
T.F. and I.T. thank financial support from NSF-DMR9458055. Most of the experiments were conducted at Polytechnic University when T.F. stayed in New York in the summer of 1999. T.F, and Y.K. acknowledge the support of a Grant-in-aid for Scientific Research on Priority Area, “Sustainable Biodegradable Plastics”, No. 11217210 (1999) from the Ministry of Education, Science, Sports and Culture.
PY - 2001
Y1 - 2001
N2 - A crude mixture of an A-B-A triblock copolymer, an A-B diblock copolymer, and B homopolymer was separated by phase fluctuation chromatography, where A is poly(L-lactic acid) and B is poly(ethylene glycol). The preparative separation method utilizes composition fluctuations occurring in a concentrated solution of the mixture. Injection of the viscous solution in a large volume into a column packed with a chemically modified stationary phase separated the mixture by the chemical composition and the number of blocks. The separation performance depended on the surface moieties, the solvent, the pore size, and the concentration. When the surface preferred B blocks and the solvent preferred A blocks, the early eluent was enriched with lactate and a triblock copolymer. The later eluent was low in the lactate content. We could not, however, find an appropriate combination of the surface moieties and the solvent that reverses the trend.
AB - A crude mixture of an A-B-A triblock copolymer, an A-B diblock copolymer, and B homopolymer was separated by phase fluctuation chromatography, where A is poly(L-lactic acid) and B is poly(ethylene glycol). The preparative separation method utilizes composition fluctuations occurring in a concentrated solution of the mixture. Injection of the viscous solution in a large volume into a column packed with a chemically modified stationary phase separated the mixture by the chemical composition and the number of blocks. The separation performance depended on the surface moieties, the solvent, the pore size, and the concentration. When the surface preferred B blocks and the solvent preferred A blocks, the early eluent was enriched with lactate and a triblock copolymer. The later eluent was low in the lactate content. We could not, however, find an appropriate combination of the surface moieties and the solvent that reverses the trend.
KW - Phase fluctuation chromatography
KW - Surface moieties
KW - Triblock copolymer
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U2 - 10.1016/S0032-3861(00)00480-8
DO - 10.1016/S0032-3861(00)00480-8
M3 - Article
AN - SCOPUS:0034139534
SN - 0032-3861
VL - 42
SP - 1067
EP - 1074
JO - Polymer
JF - Polymer
IS - 3
ER -