Serotonergic markers in atopic dermatitis

Aram Rasul, Husameldin El-Nour, Sol Britt Lonne-Rahm, Oscar Fransson, Charlotta Johansson, Björn Johansson, Marwe Zubeidi, Emma Seeberg, Diana Radu Djurfeldt, Efrain C. Azmitia, Klas Nordlind

Research output: Contribution to journalArticlepeer-review

Abstract

Stress and anxiety may worsen atopic dermatitis (AD) through the serotonin system. Serotonergic expression was measured in 28 patients with AD in relation to extent of the disease (SCORing of Atopic Dermatitis; SCORAD), pruritus intensity (visual analogue scale; VAS), anxiety traits (Swedish Universities Scales of Personality; SSP) and depression (Montgomery- Åsberg Depression Rating Scale-Self assessment; MADRS-S). Biopsies were taken from lesional and non-lesional AD skin, and investigated for expression of serotonin, its receptors 5-HT1A and 5-HT2AR, and serotonin transporter protein (SERT), using immunohistochemistry. 5-HT1AR-immunoreactivity (ir) was higher in lesional skin in apical epidermis and in mast cell-like cells in dermis, and the 5-HT2AR-ir was higher in apical epidermis and on blood vessels. In contrast, a basement membrane 5-HT2AR-ir signal was higher in non-lesional skin. The distribution of SERT-ir in the basal epidermal layer was higher in lesional skin. Positive and negative correlations were found between serotonergic markers and SCORAD, inflammation, pruritus intensity, anxiety traits, and depression score, indicating that serotonergic mechanisms are involved in AD.

Original languageEnglish (US)
Pages (from-to)732-736
Number of pages5
JournalActa Dermato-Venereologica
Volume96
Issue number6
DOIs
StatePublished - Sep 2016

Keywords

  • Atopic dermatitis
  • Inflammation
  • Pruritus
  • Serotonergic system

ASJC Scopus subject areas

  • Dermatology

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