TY - JOUR
T1 - Serotonergic mechanisms regulating the GI tract
T2 - Experimental evidence and therapeutic relevance
AU - Terry, Natalie
AU - Margolis, Kara Gross
N1 - Publisher Copyright:
© Springer International Publishing AG 2016.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Serotonin (5-hydroxytryptamine; 5-HT) is best known as a neurotransmitter critical for central nervous system (CNS) development and function. 95% of the body’s serotonin, however, is produced in the intestine where it has been increasingly recognized for its hormonal, autocrine, paracrine, and endocrine actions. This chapter provides the most current knowledge of the critical autocrine and paracrine roles of 5-HT in intestinal motility and inflammation as well as its function as a hormone in osteocyte homeostasis. Therapeutic applications in each of these areas are also discussed.
AB - Serotonin (5-hydroxytryptamine; 5-HT) is best known as a neurotransmitter critical for central nervous system (CNS) development and function. 95% of the body’s serotonin, however, is produced in the intestine where it has been increasingly recognized for its hormonal, autocrine, paracrine, and endocrine actions. This chapter provides the most current knowledge of the critical autocrine and paracrine roles of 5-HT in intestinal motility and inflammation as well as its function as a hormone in osteocyte homeostasis. Therapeutic applications in each of these areas are also discussed.
KW - Bone
KW - Enteric nervous system
KW - Intestinal inflammation
KW - Intestine
KW - Motility
KW - Serotonin
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U2 - 10.1007/164_2016_103
DO - 10.1007/164_2016_103
M3 - Article
C2 - 28035530
AN - SCOPUS:85018249769
SN - 0171-2004
VL - 239
SP - 319
EP - 342
JO - Handbook of Experimental Pharmacology
JF - Handbook of Experimental Pharmacology
ER -