@article{079a4a0e0c4b4ed5b8ecf2ec98f518a9,
title = "Serotonin and dopamine: Unifying affective, activational, and decision functions",
abstract = "Serotonin, like dopamine (DA), has long been implicated in adaptive behavior, including decision making and reinforcement learning. However, although the two neuromodulators are tightly related and have a similar degree of functional importance, compared with DA, we have a much less specific understanding about the mechanisms by which serotonin affects behavior. Here, we draw on recent work on computational models of dopaminergic function to suggest a framework by which many of the seemingly diverse functions associated with both DA and serotoninFcomprising both affective and activational ones, as well as a number of other functions not overtly related to eitherFcan be seen as consequences of a single root mechanism.",
keywords = "activation, aversion, impulsivity, inhibition, punishment, reward",
author = "Roshan Cools and Kae Nakamura and Daw, {Nathaniel D.}",
note = "Funding Information: This work was supported by a Research grant from the Human Frontiers Science Program to KN, RC, and NDD (RGP0036/2009-C). RC is also supported by a VIDI grant from the Innovational Research Incentives Scheme of the Netherlands Organisation for Scientific Research (NWO). NDD is also supported by a Scholar Award from the McKnight Foundation, a Young Investigator Award from NARSAD, and NIH grant R01MH087882-01, part of the CRCNS program. KN is supported by the Precursory for Embryonic Science and Technology, Takeda Foundation, the Nakayama Foundation, a Grant-in-Aid for Scientific Research B, and a Grant-in-Aid for Scientific Research on Priority Areas. We are grateful to our collaborators and colleagues Peter Dayan, Ben Seymour, Yael Niv, Y-Lan Boureau, Trevor Robbins, and Daniel Campbell-Meiklejohn for many useful discussions and ideas.",
year = "2011",
month = jan,
doi = "10.1038/npp.2010.121",
language = "English (US)",
volume = "36",
pages = "98--113",
journal = "Neuropsychopharmacology",
issn = "0893-133X",
publisher = "Springer Nature",
number = "1",
}