TY - JOUR
T1 - Serum taurine and risk of coronary heart disease
T2 - A prospective, nested case-control study
AU - Wójcik, Oktawia P.
AU - Koenig, Karen L.
AU - Zeleniuch-Jacquotte, Anne
AU - Pearte, Camille
AU - Costa, Max
AU - Chen, Yu
N1 - Funding Information:
Acknowledgments This research was supported by U.S. grants: NIH grants ES000260, CA16087, CA098661 and American Heart Association grant 0835569D. The authors thank Mr. Alan Bowers and Mrs. Yelena Afanasyeva for their involvement in the study.
PY - 2013/2
Y1 - 2013/2
N2 - Purpose: Taurine (2-aminoethanesulfonic acid), a molecule obtained from diet, is involved in bile acid conjugation, blood pressure regulation, anti-oxidation and anti-inflammation. We performed the first prospective study of taurine and CHD risk. Methods: We conducted a case-control study nested in the New York University Women's Health Study to evaluate the association between circulating taurine levels and risk of coronary heart disease (CHD). Taurine was measured in two yearly pre-diagnostic serum samples of 223 CHD cases and 223 matched controls and averaged for a more reliable measurement of long-term taurine levels. Results: Mean serum taurine was positively related to age and dietary intake of poultry, niacin, vitamin B1, fiber and iron, and negatively related to dietary intake of saturated fat (all p values ≤0.05). There was no statistically significant association between serum taurine levels and the risk of CHD in the overall study population. The adjusted ORs for CHD in increasing taurine tertiles were 1.0 (reference), 0.85 (95% CI, 0.51-1.40) and 0.66 (0.39-1.13; p for trend = 0.14). There was a significant inverse association between serum taurine and CHD risk among women with high total serum cholesterol (>250 mg/dL) (adjusted OR = 0.39 (0.19-0.83) for the third versus first tertile; p for trend = 0.02) but not among those with low total serum cholesterol (p for interaction = 0.01). The data suggest a possible inverse association of serum taurine with diabetes and hypertension risk. Conclusions: The findings suggest that high levels of taurine may be protective against CHD among individuals with high serum cholesterol levels.
AB - Purpose: Taurine (2-aminoethanesulfonic acid), a molecule obtained from diet, is involved in bile acid conjugation, blood pressure regulation, anti-oxidation and anti-inflammation. We performed the first prospective study of taurine and CHD risk. Methods: We conducted a case-control study nested in the New York University Women's Health Study to evaluate the association between circulating taurine levels and risk of coronary heart disease (CHD). Taurine was measured in two yearly pre-diagnostic serum samples of 223 CHD cases and 223 matched controls and averaged for a more reliable measurement of long-term taurine levels. Results: Mean serum taurine was positively related to age and dietary intake of poultry, niacin, vitamin B1, fiber and iron, and negatively related to dietary intake of saturated fat (all p values ≤0.05). There was no statistically significant association between serum taurine levels and the risk of CHD in the overall study population. The adjusted ORs for CHD in increasing taurine tertiles were 1.0 (reference), 0.85 (95% CI, 0.51-1.40) and 0.66 (0.39-1.13; p for trend = 0.14). There was a significant inverse association between serum taurine and CHD risk among women with high total serum cholesterol (>250 mg/dL) (adjusted OR = 0.39 (0.19-0.83) for the third versus first tertile; p for trend = 0.02) but not among those with low total serum cholesterol (p for interaction = 0.01). The data suggest a possible inverse association of serum taurine with diabetes and hypertension risk. Conclusions: The findings suggest that high levels of taurine may be protective against CHD among individuals with high serum cholesterol levels.
KW - Coronary heart disease
KW - Epidemiology
KW - NYUWHS
KW - Serum
KW - Taurine
UR - http://www.scopus.com/inward/record.url?scp=84872679483&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84872679483&partnerID=8YFLogxK
U2 - 10.1007/s00394-011-0300-6
DO - 10.1007/s00394-011-0300-6
M3 - Review article
C2 - 22322924
AN - SCOPUS:84872679483
SN - 1436-6207
VL - 52
SP - 169
EP - 178
JO - Zeitschrift fur Ernahrungswissenschaft
JF - Zeitschrift fur Ernahrungswissenschaft
IS - 1
ER -