Shape memory-based gastric motility 3D mapping

Neil Zixun Jia, Qiyun Gao, Vítor Sencadas, Michelle Zong, Jesse George-Akpenyi, Sylvia E. Waft, Johannes L.P. Kuosmanen, Josh Jenkins, Keiko Ishida, Alison M. Hayward, Wiam Abdalla Mohammed Madani, Niora Fabian, George Selsing, Stephanie Owyang, Khalil B. Ramadi, Ziliang Kang, Hen Wei Huang, Giovanni Traverso

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Gastrointestinal (GI) dysmotility, caused by impaired muscular contractions in the GI tract, affects 15%–20% of the population. Current clinical evaluations are limited. Here we report a motility-mapping platform that maps three-dimensional (3D) pressure distribution in the stomach, addressing gaps in existing techniques, such as high-resolution manometry. We validated the platform's measurements against existing techniques in the esophagus and rectum. A sensor probe, designed to conform to specific anatomical environments, uses body-temperature-triggered shape memory alloy to adapt to the stomach. We tested the platform's motility mapping in swine stomachs, esophagi, and rectums, both ex vivo and in vivo. This 3D in vivo characterization could transform our understanding, diagnosis, and treatment of complex GI conditions, such as functional dyspepsia.

    Original languageEnglish (US)
    Article number100010
    JournalDevice
    Volume1
    Issue number1
    DOIs
    StatePublished - Jul 21 2023

    Keywords

    • bioelectronics
    • biomedical device
    • DTI-3: Develop
    • endoscopy
    • motility

    ASJC Scopus subject areas

    • Engineering (miscellaneous)
    • Condensed Matter Physics

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