Shape memory-based gastric motility 3D mapping

Neil Zixun Jia; Qiyun Gao; Vítor Sencadas; Michelle Zong; Jesse George-Akpenyi; Sylvia E. Waft; Johannes L.P. Kuosmanen; Josh Jenkins; Keiko Ishida; Alison M. Hayward; Wiam Abdalla Mohammed Madani; Niora Fabian; George Selsing; Stephanie Owyang; Khalil B. Ramadi; Ziliang Kang; Hen Wei Huang; Giovanni Traverso

doi:10.1016/j.device.2023.100010

Shape memory-based gastric motility 3D mapping

Neil Zixun Jia, Qiyun Gao, Vítor Sencadas, Michelle Zong, Jesse George-Akpenyi, Sylvia E. Waft, Johannes L.P. Kuosmanen, Josh Jenkins, Keiko Ishida, Alison M. Hayward, Wiam Abdalla Mohammed Madani, Niora Fabian, George Selsing, Stephanie Owyang, Khalil B. Ramadi, Ziliang Kang, Hen Wei Huang, Giovanni Traverso

Research output: Contribution to journal › Article › peer-review

Abstract

Gastrointestinal (GI) dysmotility, caused by impaired muscular contractions in the GI tract, affects 15%–20% of the population. Current clinical evaluations are limited. Here we report a motility-mapping platform that maps three-dimensional (3D) pressure distribution in the stomach, addressing gaps in existing techniques, such as high-resolution manometry. We validated the platform's measurements against existing techniques in the esophagus and rectum. A sensor probe, designed to conform to specific anatomical environments, uses body-temperature-triggered shape memory alloy to adapt to the stomach. We tested the platform's motility mapping in swine stomachs, esophagi, and rectums, both ex vivo and in vivo. This 3D in vivo characterization could transform our understanding, diagnosis, and treatment of complex GI conditions, such as functional dyspepsia.

Original language	English (US)
Article number	100010
Journal	Device
Volume	1
Issue number	1
DOIs	https://doi.org/10.1016/j.device.2023.100010
State	Published - Jul 21 2023

Keywords

DTI-3: Develop
bioelectronics
biomedical device
endoscopy
motility

ASJC Scopus subject areas

Engineering (miscellaneous)
Condensed Matter Physics

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10.1016/j.device.2023.100010

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Jia, N. Z., Gao, Q., Sencadas, V., Zong, M., George-Akpenyi, J., Waft, S. E., Kuosmanen, J. L. P., Jenkins, J., Ishida, K., Hayward, A. M., Mohammed Madani, W. A., Fabian, N., Selsing, G., Owyang, S., Ramadi, K. B., Kang, Z., Huang, H. W., & Traverso, G. (2023). Shape memory-based gastric motility 3D mapping. Device, 1(1), Article 100010. https://doi.org/10.1016/j.device.2023.100010

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title = "Shape memory-based gastric motility 3D mapping",

abstract = "Gastrointestinal (GI) dysmotility, caused by impaired muscular contractions in the GI tract, affects 15%–20% of the population. Current clinical evaluations are limited. Here we report a motility-mapping platform that maps three-dimensional (3D) pressure distribution in the stomach, addressing gaps in existing techniques, such as high-resolution manometry. We validated the platform's measurements against existing techniques in the esophagus and rectum. A sensor probe, designed to conform to specific anatomical environments, uses body-temperature-triggered shape memory alloy to adapt to the stomach. We tested the platform's motility mapping in swine stomachs, esophagi, and rectums, both ex vivo and in vivo. This 3D in vivo characterization could transform our understanding, diagnosis, and treatment of complex GI conditions, such as functional dyspepsia.",

keywords = "DTI-3: Develop, bioelectronics, biomedical device, endoscopy, motility",

author = "Jia, {Neil Zixun} and Qiyun Gao and V{\'i}tor Sencadas and Michelle Zong and Jesse George-Akpenyi and Waft, {Sylvia E.} and Kuosmanen, {Johannes L.P.} and Josh Jenkins and Keiko Ishida and Hayward, {Alison M.} and {Mohammed Madani}, {Wiam Abdalla} and Niora Fabian and George Selsing and Stephanie Owyang and Ramadi, {Khalil B.} and Ziliang Kang and Huang, {Hen Wei} and Giovanni Traverso",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Inc.",

year = "2023",

month = jul,

day = "21",

doi = "10.1016/j.device.2023.100010",

language = "English (US)",

volume = "1",

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AU - Jia, Neil Zixun

AU - Gao, Qiyun

AU - Sencadas, Vítor

AU - Zong, Michelle

AU - George-Akpenyi, Jesse

AU - Waft, Sylvia E.

AU - Kuosmanen, Johannes L.P.

AU - Jenkins, Josh

AU - Ishida, Keiko

AU - Hayward, Alison M.

AU - Mohammed Madani, Wiam Abdalla

AU - Fabian, Niora

AU - Selsing, George

AU - Owyang, Stephanie

AU - Ramadi, Khalil B.

AU - Kang, Ziliang

AU - Huang, Hen Wei

AU - Traverso, Giovanni

PY - 2023/7/21

Y1 - 2023/7/21

N2 - Gastrointestinal (GI) dysmotility, caused by impaired muscular contractions in the GI tract, affects 15%–20% of the population. Current clinical evaluations are limited. Here we report a motility-mapping platform that maps three-dimensional (3D) pressure distribution in the stomach, addressing gaps in existing techniques, such as high-resolution manometry. We validated the platform's measurements against existing techniques in the esophagus and rectum. A sensor probe, designed to conform to specific anatomical environments, uses body-temperature-triggered shape memory alloy to adapt to the stomach. We tested the platform's motility mapping in swine stomachs, esophagi, and rectums, both ex vivo and in vivo. This 3D in vivo characterization could transform our understanding, diagnosis, and treatment of complex GI conditions, such as functional dyspepsia.

AB - Gastrointestinal (GI) dysmotility, caused by impaired muscular contractions in the GI tract, affects 15%–20% of the population. Current clinical evaluations are limited. Here we report a motility-mapping platform that maps three-dimensional (3D) pressure distribution in the stomach, addressing gaps in existing techniques, such as high-resolution manometry. We validated the platform's measurements against existing techniques in the esophagus and rectum. A sensor probe, designed to conform to specific anatomical environments, uses body-temperature-triggered shape memory alloy to adapt to the stomach. We tested the platform's motility mapping in swine stomachs, esophagi, and rectums, both ex vivo and in vivo. This 3D in vivo characterization could transform our understanding, diagnosis, and treatment of complex GI conditions, such as functional dyspepsia.

KW - DTI-3: Develop

KW - bioelectronics

KW - biomedical device

KW - endoscopy

KW - motility

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Shape memory-based gastric motility 3D mapping

Abstract

Keywords

ASJC Scopus subject areas

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