Shipment impairs lymphocyte proliferative responses to microbial antigens

R. A. Betensky; E. Connick; J. Devers; A. L. Landay; M. Nokta; S. Plaeger; H. Rosenblatt; J. L. Schmitz; F. Valentine; D. Wara; A. Weinberg; H. M. Lederman

doi:10.1128/CDLI.7.5.759-763.2000

Shipment impairs lymphocyte proliferative responses to microbial antigens

R. A. Betensky, E. Connick, J. Devers, A. L. Landay, M. Nokta, S. Plaeger, H. Rosenblatt, J. L. Schmitz, F. Valentine, D. Wara, A. Weinberg, H. M. Lederman

Global Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

Lymphocyte proliferation assays (LPAs) are widely used to assess T-lymphocyte function of patients with human immunodeficiency virus infection and other primary and secondary immunodeficiency disorders. Since these assays require expertise not readily available at all clinical sites, specimens may be shipped to central labs for testing. We conducted a large multicenter study to evaluate the effects of shipping on assay performance and found significant loss of LPA activity. This may lead to erroneous results for individual subjects and introduce bias into multicenter trials.

Original language	English (US)
Pages (from-to)	759-763
Number of pages	5
Journal	Clinical and Diagnostic Laboratory Immunology
Volume	7
Issue number	5
DOIs	https://doi.org/10.1128/CDLI.7.5.759-763.2000
State	Published - 2000

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Clinical Biochemistry
Microbiology (medical)

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10.1128/CDLI.7.5.759-763.2000

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title = "Shipment impairs lymphocyte proliferative responses to microbial antigens",

abstract = "Lymphocyte proliferation assays (LPAs) are widely used to assess T-lymphocyte function of patients with human immunodeficiency virus infection and other primary and secondary immunodeficiency disorders. Since these assays require expertise not readily available at all clinical sites, specimens may be shipped to central labs for testing. We conducted a large multicenter study to evaluate the effects of shipping on assay performance and found significant loss of LPA activity. This may lead to erroneous results for individual subjects and introduce bias into multicenter trials.",

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TY - JOUR

T1 - Shipment impairs lymphocyte proliferative responses to microbial antigens

AU - Betensky, R. A.

AU - Connick, E.

AU - Devers, J.

AU - Landay, A. L.

AU - Nokta, M.

AU - Plaeger, S.

AU - Rosenblatt, H.

AU - Schmitz, J. L.

AU - Valentine, F.

AU - Wara, D.

AU - Weinberg, A.

AU - Lederman, H. M.

PY - 2000

Y1 - 2000

N2 - Lymphocyte proliferation assays (LPAs) are widely used to assess T-lymphocyte function of patients with human immunodeficiency virus infection and other primary and secondary immunodeficiency disorders. Since these assays require expertise not readily available at all clinical sites, specimens may be shipped to central labs for testing. We conducted a large multicenter study to evaluate the effects of shipping on assay performance and found significant loss of LPA activity. This may lead to erroneous results for individual subjects and introduce bias into multicenter trials.

AB - Lymphocyte proliferation assays (LPAs) are widely used to assess T-lymphocyte function of patients with human immunodeficiency virus infection and other primary and secondary immunodeficiency disorders. Since these assays require expertise not readily available at all clinical sites, specimens may be shipped to central labs for testing. We conducted a large multicenter study to evaluate the effects of shipping on assay performance and found significant loss of LPA activity. This may lead to erroneous results for individual subjects and introduce bias into multicenter trials.

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AN - SCOPUS:0033823622

SN - 1071-412X

VL - 7

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EP - 763

JO - Clinical and Diagnostic Laboratory Immunology

JF - Clinical and Diagnostic Laboratory Immunology

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ER -

Shipment impairs lymphocyte proliferative responses to microbial antigens

Abstract

ASJC Scopus subject areas

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