Shipment impairs lymphocyte proliferative responses to microbial antigens

R. A. Betensky, E. Connick, J. Devers, A. L. Landay, M. Nokta, S. Plaeger, H. Rosenblatt, J. L. Schmitz, F. Valentine, D. Wara, A. Weinberg, H. M. Lederman

Research output: Contribution to journalArticle

Abstract

Lymphocyte proliferation assays (LPAs) are widely used to assess T-lymphocyte function of patients with human immunodeficiency virus infection and other primary and secondary immunodeficiency disorders. Since these assays require expertise not readily available at all clinical sites, specimens may be shipped to central labs for testing. We conducted a large multicenter study to evaluate the effects of shipping on assay performance and found significant loss of LPA activity. This may lead to erroneous results for individual subjects and introduce bias into multicenter trials.

Original languageEnglish (US)
Pages (from-to)759-763
Number of pages5
JournalClinical and Diagnostic Laboratory Immunology
Volume7
Issue number5
DOIs
StatePublished - 2000

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Clinical Biochemistry
  • Microbiology (medical)

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    Betensky, R. A., Connick, E., Devers, J., Landay, A. L., Nokta, M., Plaeger, S., Rosenblatt, H., Schmitz, J. L., Valentine, F., Wara, D., Weinberg, A., & Lederman, H. M. (2000). Shipment impairs lymphocyte proliferative responses to microbial antigens. Clinical and Diagnostic Laboratory Immunology, 7(5), 759-763. https://doi.org/10.1128/CDLI.7.5.759-763.2000