Short chain fatty acids produced by anaerobic bacteria inhibit adhesion and proliferation of periodontal ligament fibroblasts.

C. Eftimiadi, S. Valente, S. Mangiante, P. E. Mangiante, R. Niederman

Research output: Contribution to journalArticle

Abstract

Short chain fatty acids (SCFA) are metabolic by-products of anaerobic bacteria present in the periodontal pocket. We examined the effect of SCFA on cultured human periodontal ligament fibroblasts (PDLF). PDLF were challenged with propionate, butyrate and succinate. A dose dependent inhibition of fibroblast adhesion and proliferation was observed. These results indicate that SCFA present in the periodontal pockets could interfere with periodontal wound healing and repair in patients affected by periodontal infections.

Original languageEnglish (US)
Pages (from-to)481-485
Number of pages5
JournalMinerva stomatologica
Volume42
Issue number11-12
StatePublished - Nov 1993

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

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