TY - JOUR
T1 - Signal transduction in the early Drosophila embryo
T2 - when genetics meets biochemistry
AU - Perrimon, Norbert
AU - Desplan, Claude
PY - 1994/11
Y1 - 1994/11
N2 - An elegant combination of genetic and biochemical approaches has been used to investigate a variety of signal transduction pathways in developmental processes. Here, we describe the 'terminal' signaling system in the Drosophila embryo, which is responsible for pattern formation in the polar regions of the embryo. This pathway involves a membrane-bound receptor tyrosine kinase (RTK) that is similar to other Drosophila RTKs, such as sevenless, and the mammalian RTKs, such as the epidermal growth factor or platelet-derived growth factor receptors.
AB - An elegant combination of genetic and biochemical approaches has been used to investigate a variety of signal transduction pathways in developmental processes. Here, we describe the 'terminal' signaling system in the Drosophila embryo, which is responsible for pattern formation in the polar regions of the embryo. This pathway involves a membrane-bound receptor tyrosine kinase (RTK) that is similar to other Drosophila RTKs, such as sevenless, and the mammalian RTKs, such as the epidermal growth factor or platelet-derived growth factor receptors.
UR - http://www.scopus.com/inward/record.url?scp=0028019361&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028019361&partnerID=8YFLogxK
U2 - 10.1016/0968-0004(94)90140-6
DO - 10.1016/0968-0004(94)90140-6
M3 - Article
C2 - 7855897
AN - SCOPUS:0028019361
SN - 0968-0004
VL - 19
SP - 509
EP - 513
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
IS - 11
ER -