Abstract
Disubstituted α-hydroxy acids have been synthesized by metal-catalyzed silylene transfer to α-keto esters. A range of substituents are tolerated in the transformation with the exception of branched groups at the vinylic position. The α-hydroxy acid products can be converted into γ-lactones using a variety of lactonization conditions.
Original language | English (US) |
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Pages (from-to) | 6447-6453 |
Number of pages | 7 |
Journal | Tetrahedron |
Volume | 65 |
Issue number | 33 |
DOIs | |
State | Published - Aug 15 2009 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry