Silylene transfer to α-keto esters and application to the synthesis of γ-lactones

Brett E. Howard, K. A. Woerpel

Research output: Contribution to journalArticle

Abstract

Disubstituted α-hydroxy acids have been synthesized by metal-catalyzed silylene transfer to α-keto esters. A range of substituents are tolerated in the transformation with the exception of branched groups at the vinylic position. The α-hydroxy acid products can be converted into γ-lactones using a variety of lactonization conditions.

Original languageEnglish (US)
Pages (from-to)6447-6453
Number of pages7
JournalTetrahedron
Volume65
Issue number33
DOIs
StatePublished - Aug 15 2009

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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