Simple and practical sequence nearest neighbors with block operations

S. Muthu Muthukrishnan, S. Cenk Ṣahinalp

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Sequence nearest neighbors problemcan be defined as follows. Given a database D of n sequences, preprocess D so that given any query sequence Q, one can quickly find a sequence S in D for which d(S, Q) ≤ d(S, T) for any other sequence T in D. Here d(S, Q) denotes the “distance” between sequences S and Q, which can be defined as the minimum number of “edit operations” to transform one sequence into the other. The edit operations considered in this paper include single character edits (insertions, deletions, replacements) as well as block (substring) edits (copying, uncopying and relocating blocks). One of the main application domains for the sequence nearest neighbors problem is computational genomics where available tools for sequence comparison and search usually focus on edit operations involving single characters only. While such tools are useful for capturing certain evolutionary mechanisms (mainly point mutations), they may have limited applicability for understanding mechanisms for segmental rearrangements (duplications, translocations and deletions) underlying genome evolution. Recent improvements towards the resolution of the human genome composition suggest that such segmental rearrangements are much more common than what was estimated before. Thus there is substantial need for incorporating similarity measures that capture block edit operations in genomic sequence comparison and search.1 Unfortunately even the computation of a block edit distance between two sequences under any set of non-trivial edit operations is NP-hard. The first efficient data structure for approximate sequence nearest neighbor search for any set of non-trivial edit operations were described in [11]; the measure considered in this paper is the block edit distance. This method achieves a preprocessing time and space polynomial in size of D and query time near-linear in size of Q by allowing an approximate factor of O (log £ (log* £)). The approach involves embedding sequences into Hamming space so that approximating Hamming distances estimates sequence block edit distances within the approximation ratio above. In this study we focus on simplification and experimental evaluation of the [11] method. We first describe how we implement and test the accuracy of the transformations provided in [] in terms of estimating the block edit distance under controlled data sets. Then, based on the hamming distance estimator described in [3] we present a data structure for computing approximate nearest neighbors in hamming space; this is simpler than the well-known ones in [9,6]. We finally report on how well the combined data structure performs for sequence nearest neighbor search under block edit distance.

    Original languageEnglish (US)
    Title of host publicationCombinatorial Pattern Matching - 13th Annual Symposium, CPM 2002, Proceedings
    EditorsAlberto Apostolico, Masayuki Takeda
    PublisherSpringer Verlag
    Pages262-278
    Number of pages17
    ISBN (Electronic)9783540438625
    DOIs
    StatePublished - 2002
    Event13th Annual Symposium on Combinatorial Pattern Matching, CPM 2002 - Fukuoka, Japan
    Duration: Jul 3 2002Jul 5 2002

    Publication series

    NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
    Volume2373
    ISSN (Print)0302-9743
    ISSN (Electronic)1611-3349

    Conference

    Conference13th Annual Symposium on Combinatorial Pattern Matching, CPM 2002
    CountryJapan
    CityFukuoka
    Period7/3/027/5/02

    ASJC Scopus subject areas

    • Theoretical Computer Science
    • Computer Science(all)

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