Simple spike dynamics of Purkinje cells in the macaque vestibulo-cerebellum during passive whole-body self-motion

Jean Laurens, Dora E. Angelaki

Research output: Contribution to journalArticle

Abstract

Theories of cerebellar functions posit that the cerebellum implements internal models for online correction of motor actions and sensory estimation. As an example of such computations, an internal model resolves a sensory ambiguity where the peripheral otolith organs in the inner ear sense both head tilts and translations. Here we exploit the response dynamics of two functionally coupled Purkinje cell types in the vestibular part of the caudal vermis (lobules IX and X) to understand their role in this computation. We find that one population encodes tilt velocity, whereas the other, translation-selective, population encodes linear acceleration. We predict that an intermediate neuronal type should temporally integrate the output of tilt-selective cells into a tilt position signal.

Original languageEnglish (US)
Pages (from-to)3232-3238
Number of pages7
JournalProceedings of the National Academy of Sciences of the United States of America
Volume117
Issue number6
DOIs
StatePublished - Feb 11 2020

Keywords

  • Cerebellum
  • Internal model
  • Vestibular

ASJC Scopus subject areas

  • General

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