@article{eaeddb0e541f4662b7ae1fc168dd8d8f,
title = "Single-cell delineation of lineage and genetic identity in the mouse brain",
abstract = "During neurogenesis, mitotic progenitor cells lining the ventricles of the embryonic mouse brain undergo their final rounds of cell division, giving rise to a wide spectrum of postmitotic neurons and glia1,2. The link between developmental lineage and cell-type diversity remains an open question. Here we used massively parallel tagging of progenitors to track clonal relationships and transcriptomic signatures during mouse forebrain development. We quantified clonal divergence and convergence across all major cell classes postnatally, and found diverse types of GABAergic neuron that share a common lineage. Divergence of GABAergic clones occurred during embryogenesis upon cell-cycle exit, suggesting that differentiation into subtypes is initiated as a lineage-dependent process at the progenitor cell level.",
author = "Bandler, {Rachel C.} and Ilaria Vitali and Delgado, {Ryan N.} and Ho, {May C.} and Elena Dvoretskova and {Ibarra Molinas}, {Josue S.} and Frazel, {Paul W.} and Maesoumeh Mohammadkhani and Robert Machold and Sophia Maedler and Liddelow, {Shane A.} and Nowakowski, {Tomasz J.} and Gord Fishell and Christian Mayer",
note = "Funding Information: Acknowledgements We thank members of the Mayer laboratory, H. Baier, A. Borst, W. Denk, G. Evrony, A. Fabritius, M. G{\"o}tz and R. Satija for feedback and discussion; J. Kuhl (somedonkey. com) for illustrations; M. Driessen and R. H. Kim from the MPIB Next Generation Sequencing core facility, I. Velasques and G. Eckstein from the Genomics Core facility at the Helmholtz Zentrum M{\"u}nchen (HMGU), M. Spitaler and M. Oster from the MPIB Imaging and FACS core facility, M. Gregory, C. Zollo and K. Ryan from the NYU FACS core facility, R. Kasper from the MPIN Imaging core facility, M. Fischer from the IT department and members of the MPIB/ MPIN animal facility for their technical expertise. This work was supported by the Max-Planck Society, the European Research Council (ERC) under the European Union{\textquoteright}s Horizon 2020 Research and Innovation program (ERC-2018-STG, grant agreement no. 803984) (to C.M.), the Simons Foundation (to G.F.), NIH 5R01NS081297-07 (to G.F.), 1UG3MH120096-01 (to G.F.), NIH 5R01MH071679-15 (to G.F.), RF1MH121268 from NIMH a Broad Center Regenerative Medicine & Stem Cell Research Innovation Award, a gift from the Bowes Foundation (to T.J.N.), generous anonymous donors, the Cure Alzheimer{\textquoteright}s Fund, The Blas Frangione Foundation, NIH R21NS111186 (to S.A.L.), NYU School of Medicine (to S.A.L. and R.C.B.), NIH F30MH114462 (to R.C.B.), T32GM007308 (to R.C.B.) and NIH P01NS074972 (to R.M.). Publisher Copyright: {\textcopyright} 2021, The Author(s).",
year = "2022",
month = jan,
day = "20",
doi = "10.1038/s41586-021-04237-0",
language = "English (US)",
volume = "601",
pages = "404--409",
journal = "Nature Cell Biology",
issn = "1465-7392",
publisher = "Nature Publishing Group",
number = "7893",
}