@article{05c4ecc0493e41f5b00658278b307d89,
title = "Single injection of ketamine during mid-adolescence promotes long-lasting resilience to activity-based anorexia of female mice by increasing food intake and attenuating hyperactivity as well as anxiety-like behavior",
abstract = "Objective: This study tested the effects of ketamine on vulnerability of female adolescent mice to activity-based anorexia (ABA). Method: Twenty-four female C57Bl/6 J mice underwent ABA induction, which involved exposing wheel-acclimated adolescent mice to two bouts of food restriction (FR)—the first ABA (P41–44, mid-adolescence) and the second ABA (P55–59, late adolescence), with recovery in between. Ketamine (3 or 30 mg/kg) or vehicle was given once, on the second day of FR of the first ABA (P42). Food consumption, body weight and wheel running activity were measured daily. Anxiety-like behaviors were accessed by elevated plus maze on P49 and P62, after weight restoration during the recovery phase. Results: Ketamine (30 mg/kg) increased food intake during the first ABA (+38%, p =.015) and facilitated weight gain during recovery (+42%, p =.003). During the second ABA, the effect was manifested as increased food intake (+38%, p =.001) and weight gain (+47%, p =.001) while attenuating FR-induced wheel running activity (−24%, p =.09) and weight loss (−17%, p =.056). Ketamine also reduced anxiety-like behaviors. Discussion: Thus, single injection of ketamine during mid-adolescence effectively attenuates vulnerability of female mice to repeated ABA exposures.",
keywords = "ABA, C57BL6/J, EPM, adolescence, anxiety-like behavior, body weight, food intake, hyperactivity, ketamine, rodent",
author = "Chen, {Yi Wen} and Sherpa, {Ang Doma} and Chiye Aoki",
note = "Funding Information: information Fulbright Scholarship, Grant/Award Number: no number; Klarman Family Foundation Grant Program in Eating Disorders Research, Grant/Award Number: R21 MH105846; R01NS066019-01A1, R01NS047557-07A1; National Eye Institute, Grant/Award Number:EY13079; National Institute of Mental Health, Grant/Award Number:R21 MH105846; National Institutes of Health, Grant/Award Number: R01NS047557-07A1,R01NS066019-01A1; National Science Foundation, Grant/Award Number: NSF-REU 1460880; NYU Research Challenge Fund, Grant/Award Number: NSF-REU 1460880This study was supported by The Klarman Family Foundation Grant Program in Eating Disorders Research, Grant number: R21 MH105846; Grant number: R01NS066019-01A1; Grant number: R01NS047557-07A1; Grant number: NEI Core grant EY13079; NYU's Research Challenge Fund, Grant number: NSF-REU 1460880 to CA, YWC, and the Fulbright Scholarship to YWC. Funding Information: Fulbright Scholarship, Grant/Award Number: no number; Klarman Family Foundation Grant Program in Eating Disorders Research, Grant/ Award Number: R21 MH105846, R01NS066019-01A1, R01NS047557-07A1; National Eye Institute, Grant/Award Number: EY13079; National Institute of Mental Health, Grant/Award Number: R21 MH105846; National Institutes of Health, Grant/Award Number: R01NS047557-07A1, R01NS066019-01A1; National Science Foundation, Grant/Award Number: NSF-REU 1460880 ; NYU Research Challenge Fund, Grant/Award Number: NSF-REU 1460880 Funding Information: This study was supported by The Klarman Family Foundation Grant Program in Eating Disorders Research, Grant number: R21 MH105846; Grant number: R01NS066019-01A1; Grant number: R01NS047557-07A1; Grant number: NEI Core grant EY13079; NYU's Research Challenge Fund, Grant number: NSF-REU 1460880 to CA, YWC, and the Fulbright Scholarship to YWC. Publisher Copyright: {\textcopyright} 2018 Wiley Periodicals, Inc.",
year = "2018",
month = aug,
doi = "10.1002/eat.22937",
language = "English (US)",
volume = "51",
pages = "1020--1025",
journal = "International Journal of Eating Disorders",
issn = "0276-3478",
publisher = "John Wiley and Sons Inc.",
number = "8",
}