Single nucleotide polymorphisms associated with aggressive periodontitis and severe chronic periodontitis in Japanese

Asami Suzuki; Guijin Ji; Yukihiro Numabe; Masaaki Muramatsu; Kazuhiro Gomi; Mikimoto Kanazashi; Yorimasa Ogata; Emi Shimizu; Yoshihiro Shibukawa; Akiyo Ito; Taichi Ito; Akira Sugaya; Takashi Arai; Satoru Yamada; Shinji Deguchi; Kyuichi Kamoi

doi:10.1016/j.bbrc.2004.03.126

Single nucleotide polymorphisms associated with aggressive periodontitis and severe chronic periodontitis in Japanese

Asami Suzuki, Guijin Ji, Yukihiro Numabe, Masaaki Muramatsu, Kazuhiro Gomi, Mikimoto Kanazashi, Yorimasa Ogata, Emi Shimizu, Yoshihiro Shibukawa, Akiyo Ito, Taichi Ito, Akira Sugaya, Takashi Arai, Satoru Yamada, Shinji Deguchi, Kyuichi Kamoi

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Abstract

Periodontitis is a common inflammatory disease causing destruction of periodontal tissues. It is a multifactor disease involving genetic factors and oral environmental factors. To determine genetic risk factors associated with aggressive periodontitis or severe chronic periodontitis, single nucleotide polymorphisms (SNPs) in multiple candidate genes were investigated in Japanese. We studied 134 patients with aggressive periodontitis, 117 patients with severe chronic periodontitis, and 125 healthy volunteers without periodontitis, under case-control setting, and 310 SNPs in 125 candidate genes were genotyped. Association evaluation by Fisher's exact test (p<0.01) revealed statistically significant SNPs in multiple genes, not only in inflammatory mediators (IL6ST and PTGDS, associated with aggressive periodontitis; and CTSD, associated with severe chronic periodontitis), but also in structural factors of periodontal tissues (COL4A1, COL1A1, and KRT23, associated with aggressive periodontitis; and HSPG2, COL17A1, and EGF, associated with severe chronic periodontitis). These appear to be good candidates as genetic factors for future study.

Original language	English (US)
Pages (from-to)	887-892
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	317
Issue number	3
DOIs	https://doi.org/10.1016/j.bbrc.2004.03.126
State	Published - May 7 2004

Keywords

Aggressive periodontitis
Inflammatory mediators
Severe chronic periodontitis
Single nucleotide polymorphisms
Structural factors of periodontal tissues

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2004.03.126

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Suzuki, A., Ji, G., Numabe, Y., Muramatsu, M., Gomi, K., Kanazashi, M., Ogata, Y., Shimizu, E., Shibukawa, Y., Ito, A., Ito, T., Sugaya, A., Arai, T., Yamada, S., Deguchi, S., & Kamoi, K. (2004). Single nucleotide polymorphisms associated with aggressive periodontitis and severe chronic periodontitis in Japanese. Biochemical and Biophysical Research Communications, 317(3), 887-892. https://doi.org/10.1016/j.bbrc.2004.03.126

Suzuki, A, Ji, G, Numabe, Y, Muramatsu, M, Gomi, K, Kanazashi, M, Ogata, Y, Shimizu, E, Shibukawa, Y, Ito, A, Ito, T, Sugaya, A, Arai, T, Yamada, S, Deguchi, S & Kamoi, K 2004, 'Single nucleotide polymorphisms associated with aggressive periodontitis and severe chronic periodontitis in Japanese', Biochemical and Biophysical Research Communications, vol. 317, no. 3, pp. 887-892. https://doi.org/10.1016/j.bbrc.2004.03.126

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abstract = "Periodontitis is a common inflammatory disease causing destruction of periodontal tissues. It is a multifactor disease involving genetic factors and oral environmental factors. To determine genetic risk factors associated with aggressive periodontitis or severe chronic periodontitis, single nucleotide polymorphisms (SNPs) in multiple candidate genes were investigated in Japanese. We studied 134 patients with aggressive periodontitis, 117 patients with severe chronic periodontitis, and 125 healthy volunteers without periodontitis, under case-control setting, and 310 SNPs in 125 candidate genes were genotyped. Association evaluation by Fisher's exact test (p<0.01) revealed statistically significant SNPs in multiple genes, not only in inflammatory mediators (IL6ST and PTGDS, associated with aggressive periodontitis; and CTSD, associated with severe chronic periodontitis), but also in structural factors of periodontal tissues (COL4A1, COL1A1, and KRT23, associated with aggressive periodontitis; and HSPG2, COL17A1, and EGF, associated with severe chronic periodontitis). These appear to be good candidates as genetic factors for future study.",

keywords = "Aggressive periodontitis, Inflammatory mediators, Severe chronic periodontitis, Single nucleotide polymorphisms, Structural factors of periodontal tissues",

author = "Asami Suzuki and Guijin Ji and Yukihiro Numabe and Masaaki Muramatsu and Kazuhiro Gomi and Mikimoto Kanazashi and Yorimasa Ogata and Emi Shimizu and Yoshihiro Shibukawa and Akiyo Ito and Taichi Ito and Akira Sugaya and Takashi Arai and Satoru Yamada and Shinji Deguchi and Kyuichi Kamoi",

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AU - Suzuki, Asami

AU - Ji, Guijin

AU - Numabe, Yukihiro

AU - Muramatsu, Masaaki

AU - Gomi, Kazuhiro

AU - Kanazashi, Mikimoto

AU - Ogata, Yorimasa

AU - Shimizu, Emi

AU - Shibukawa, Yoshihiro

AU - Ito, Akiyo

AU - Ito, Taichi

AU - Sugaya, Akira

AU - Arai, Takashi

AU - Yamada, Satoru

AU - Deguchi, Shinji

AU - Kamoi, Kyuichi

PY - 2004/5/7

Y1 - 2004/5/7

N2 - Periodontitis is a common inflammatory disease causing destruction of periodontal tissues. It is a multifactor disease involving genetic factors and oral environmental factors. To determine genetic risk factors associated with aggressive periodontitis or severe chronic periodontitis, single nucleotide polymorphisms (SNPs) in multiple candidate genes were investigated in Japanese. We studied 134 patients with aggressive periodontitis, 117 patients with severe chronic periodontitis, and 125 healthy volunteers without periodontitis, under case-control setting, and 310 SNPs in 125 candidate genes were genotyped. Association evaluation by Fisher's exact test (p<0.01) revealed statistically significant SNPs in multiple genes, not only in inflammatory mediators (IL6ST and PTGDS, associated with aggressive periodontitis; and CTSD, associated with severe chronic periodontitis), but also in structural factors of periodontal tissues (COL4A1, COL1A1, and KRT23, associated with aggressive periodontitis; and HSPG2, COL17A1, and EGF, associated with severe chronic periodontitis). These appear to be good candidates as genetic factors for future study.

AB - Periodontitis is a common inflammatory disease causing destruction of periodontal tissues. It is a multifactor disease involving genetic factors and oral environmental factors. To determine genetic risk factors associated with aggressive periodontitis or severe chronic periodontitis, single nucleotide polymorphisms (SNPs) in multiple candidate genes were investigated in Japanese. We studied 134 patients with aggressive periodontitis, 117 patients with severe chronic periodontitis, and 125 healthy volunteers without periodontitis, under case-control setting, and 310 SNPs in 125 candidate genes were genotyped. Association evaluation by Fisher's exact test (p<0.01) revealed statistically significant SNPs in multiple genes, not only in inflammatory mediators (IL6ST and PTGDS, associated with aggressive periodontitis; and CTSD, associated with severe chronic periodontitis), but also in structural factors of periodontal tissues (COL4A1, COL1A1, and KRT23, associated with aggressive periodontitis; and HSPG2, COL17A1, and EGF, associated with severe chronic periodontitis). These appear to be good candidates as genetic factors for future study.

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KW - Severe chronic periodontitis

KW - Single nucleotide polymorphisms

KW - Structural factors of periodontal tissues

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Single nucleotide polymorphisms associated with aggressive periodontitis and severe chronic periodontitis in Japanese

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Keywords

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