Six-helix bundles designed from DNA

Frederick Mathieu, Shiping Liao, Jens Kopatsch, Tong Wang, Chengde Mao, Nadrian C. Seeman

Research output: Contribution to journalArticlepeer-review


We present a designed cyclic DNA motif that consists of six DNA double helices that are connected to each other at two crossover sites. DNA double helices with 10.5 nucleotide pairs per turn facilitate the programming of DNA double crossover molecules to form hexagonally symmetric arrangements when the crossover points are separated by seven or fourteen nucleotide pairs. We demonstrate by atomic force microscopy well-formed arrays of hexagonal six-helix bundle motifs both in 1D and in 2D.

Original languageEnglish (US)
Pages (from-to)661-665
Number of pages5
JournalNano Letters
Issue number4
StatePublished - Apr 2005

ASJC Scopus subject areas

  • Bioengineering
  • General Chemistry
  • General Materials Science
  • Condensed Matter Physics
  • Mechanical Engineering


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