TY - JOUR
T1 - Sleep regulation of the distribution of cortical firing rates
AU - Levenstein, Daniel
AU - Watson, Brendon O.
AU - Rinzel, John
AU - Buzsáki, György
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Sleep is thought to mediate both mnemonic and homeostatic functions. However, the mechanism by which this brain state can simultaneously implement the ‘selective’ plasticity needed to consolidate novel memory traces and the ‘general’ plasticity necessary to maintain a well-functioning neuronal system is unclear. Recent findings show that both of these functions differentially affect neurons based on their intrinsic firing rate, a ubiquitous neuronal heterogeneity. Furthermore, they are both implemented by the NREM slow oscillation, which also distinguishes neurons based on firing rate during sequential activity at the DOWN → UP transition. These findings suggest a mechanism by which spiking activity during the slow oscillation acts to maintain network statistics that promote a skewed distribution of neuronal firing rates, and perturbation of that activity by hippocampal replay acts to integrate new memory traces into the existing cortical network.
AB - Sleep is thought to mediate both mnemonic and homeostatic functions. However, the mechanism by which this brain state can simultaneously implement the ‘selective’ plasticity needed to consolidate novel memory traces and the ‘general’ plasticity necessary to maintain a well-functioning neuronal system is unclear. Recent findings show that both of these functions differentially affect neurons based on their intrinsic firing rate, a ubiquitous neuronal heterogeneity. Furthermore, they are both implemented by the NREM slow oscillation, which also distinguishes neurons based on firing rate during sequential activity at the DOWN → UP transition. These findings suggest a mechanism by which spiking activity during the slow oscillation acts to maintain network statistics that promote a skewed distribution of neuronal firing rates, and perturbation of that activity by hippocampal replay acts to integrate new memory traces into the existing cortical network.
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U2 - 10.1016/j.conb.2017.02.013
DO - 10.1016/j.conb.2017.02.013
M3 - Review article
C2 - 28288386
AN - SCOPUS:85014925150
VL - 44
SP - 34
EP - 42
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
SN - 0959-4388
ER -