TY - JOUR
T1 - Slicing across Kingdoms
T2 - Regeneration in Plants and Animals
AU - Birnbaum, Kenneth D.
AU - Alvarado, Alejandro Sánchez
N1 - Funding Information:
The authors thank T. Piotrowski and B. Bargmann for their critical reading of the manuscript. A.S.A. is an investigator of the Howard Hughes Medical Institute. NIH-NIGMS RO-1 GM57260 to A.S.A. supported work described in this manuscript. The regeneration research of K.D.B. is supported by NIH-NIGMS RO-1 GM078279.
PY - 2008/2/22
Y1 - 2008/2/22
N2 - Multicellular organisms possessing relatively long life spans are subjected to diverse, constant, and often intense intrinsic and extrinsic challenges to their survival. Animal and plant tissues wear out as part of normal physiological functions and can be lost to predators, disease, and injury. Both kingdoms survive this wide variety of insults by strategies that include the maintenance of adult stem cells or the induction of stem cell potential in differentiated cells. Repatterning mechanisms often deploy embryonic genes, but the question remains in both plants and animals whether regeneration invokes embryogenesis, generic patterning mechanisms, or unique circuitry comprised of well-established patterning genes.
AB - Multicellular organisms possessing relatively long life spans are subjected to diverse, constant, and often intense intrinsic and extrinsic challenges to their survival. Animal and plant tissues wear out as part of normal physiological functions and can be lost to predators, disease, and injury. Both kingdoms survive this wide variety of insults by strategies that include the maintenance of adult stem cells or the induction of stem cell potential in differentiated cells. Repatterning mechanisms often deploy embryonic genes, but the question remains in both plants and animals whether regeneration invokes embryogenesis, generic patterning mechanisms, or unique circuitry comprised of well-established patterning genes.
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U2 - 10.1016/j.cell.2008.01.040
DO - 10.1016/j.cell.2008.01.040
M3 - Review article
C2 - 18295584
AN - SCOPUS:39149100320
SN - 0092-8674
VL - 132
SP - 697
EP - 710
JO - Cell
JF - Cell
IS - 4
ER -