Smoking cessation patterns in methadone-maintained smokers

Michael D. Stein, Bradley J. Anderson, Raymond Niaura

Research output: Contribution to journalArticlepeer-review


To determine predictors of smoking cessation duration in a randomized clinical trial, we assigned participants to nicotine patch (8-12 weeks) plus either (a) a baseline tailored brief motivational intervention, a quit date behavioral skills counseling session, and a relapse prevention follow-up session, or (b) brief advice using the National Cancer Institute's 4A's model. A total of 383 smokers from five methadone maintenance treatment centers in Rhode Island were enrolled, of whom 312 (82%) completed 6-month follow-up assessments. The primary outcome was longest period of self-reported abstinence during follow-up. Participants were on average 40.5 years of age; 51.9% were male, and 77.6% were White. In multivariate analysis controlling for demographics, nicotine dependence, depressive symptoms, and smoking-related symptoms, we found longer periods of abstinence in persons reporting at least one 24-hr quit attempt in the year prior to baseline (OR = 1.97, p =.003), in those anticipating success in cessation (OR = 1.33, p =.024), and in those with a greater percentage of nicotine patch use days (OR = 2.78, p <.001). Past quit attempts, self-efficacy, and constant nicotine replacement were associated with duration of abstinence among methadone-maintained smokers. Attention to these domains in future intervention studies may improve treatment success.

Original languageEnglish (US)
Pages (from-to)421-428
Number of pages8
JournalNicotine and Tobacco Research
Issue number3
StatePublished - Mar 2007

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health


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