Smoking is associated with mosaic loss of chromosome Y

Jan P. Dumanski; Chiara Rasi; Mikael Lönn; Hanna Davies; Martin Ingelsson; Vilmantas Giedraitis; Lars Lannfelt; Patrik K.E. Magnusson; Cecilia M. Lindgren; Andrew P. Morris; David Cesarini; Magnus Johannesson; Eva Tiensuu Janson; Lars Lind; Nancy L. Pedersen; Erik Ingelsson; Lars A. Forsberg

doi:10.1126/science.1262092

Smoking is associated with mosaic loss of chromosome Y

Jan P. Dumanski, Chiara Rasi, Mikael Lönn, Hanna Davies, Martin Ingelsson, Vilmantas Giedraitis, Lars Lannfelt, Patrik K.E. Magnusson, Cecilia M. Lindgren, Andrew P. Morris, David Cesarini, Magnus Johannesson, Eva Tiensuu Janson, Lars Lind, Nancy L. Pedersen, Erik Ingelsson, Lars A. Forsberg

Research output: Contribution to journal › Article › peer-review

Abstract

Tobacco smoking is a risk factor for numerous disorders, including cancers affecting organs outside the respiratory tract. Epidemiological data suggest that smoking is a greater risk factor for these cancers in males compared with females. This observation, together with the fact that males have a higher incidence of and mortality from most non-sex-specific cancers, remains unexplained. Loss of chromosome Y (LOY) in blood cells is associated with increased risk of nonhematological tumors. We demonstrate here that smoking is associated with LOY in blood cells in three independent cohorts [TwinGene: odds ratio (OR) = 4.3, 95% confidence interval (CI) = 2.8 to 6.7; Uppsala Longitudinal Study of Adult Men: OR = 2.4, 95% CI = 1.6 to 3.6; and Prospective Investigation of the Vasculature in Uppsala Seniors: OR = 3.5, 95% CI = 1.4 to 8.4] encompassing a total of 6014 men. The data also suggest that smoking has a transient and dose-dependent mutagenic effect on LOY status. The finding that smoking induces LOY thus links a preventable risk factor with the most common acquired human mutation.

Original language	English (US)
Pages (from-to)	81-83
Number of pages	3
Journal	Science
Volume	347
Issue number	6217
DOIs	https://doi.org/10.1126/science.1262092
State	Published - Jan 2 2015

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Dumanski, J. P., Rasi, C., Lönn, M., Davies, H., Ingelsson, M., Giedraitis, V., Lannfelt, L., Magnusson, P. K. E., Lindgren, C. M., Morris, A. P., Cesarini, D., Johannesson, M., Janson, E. T., Lind, L., Pedersen, N. L., Ingelsson, E., & Forsberg, L. A. (2015). Smoking is associated with mosaic loss of chromosome Y. Science, 347(6217), 81-83. https://doi.org/10.1126/science.1262092

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title = "Smoking is associated with mosaic loss of chromosome Y",

abstract = "Tobacco smoking is a risk factor for numerous disorders, including cancers affecting organs outside the respiratory tract. Epidemiological data suggest that smoking is a greater risk factor for these cancers in males compared with females. This observation, together with the fact that males have a higher incidence of and mortality from most non-sex-specific cancers, remains unexplained. Loss of chromosome Y (LOY) in blood cells is associated with increased risk of nonhematological tumors. We demonstrate here that smoking is associated with LOY in blood cells in three independent cohorts [TwinGene: odds ratio (OR) = 4.3, 95% confidence interval (CI) = 2.8 to 6.7; Uppsala Longitudinal Study of Adult Men: OR = 2.4, 95% CI = 1.6 to 3.6; and Prospective Investigation of the Vasculature in Uppsala Seniors: OR = 3.5, 95% CI = 1.4 to 8.4] encompassing a total of 6014 men. The data also suggest that smoking has a transient and dose-dependent mutagenic effect on LOY status. The finding that smoking induces LOY thus links a preventable risk factor with the most common acquired human mutation.",

author = "Dumanski, {Jan P.} and Chiara Rasi and Mikael L{\"o}nn and Hanna Davies and Martin Ingelsson and Vilmantas Giedraitis and Lars Lannfelt and Magnusson, {Patrik K.E.} and Lindgren, {Cecilia M.} and Morris, {Andrew P.} and David Cesarini and Magnus Johannesson and Janson, {Eva Tiensuu} and Lars Lind and Pedersen, {Nancy L.} and Erik Ingelsson and Forsberg, {Lars A.}",

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doi = "10.1126/science.1262092",

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T1 - Smoking is associated with mosaic loss of chromosome Y

AU - Dumanski, Jan P.

AU - Rasi, Chiara

AU - Lönn, Mikael

AU - Davies, Hanna

AU - Ingelsson, Martin

AU - Giedraitis, Vilmantas

AU - Lannfelt, Lars

AU - Magnusson, Patrik K.E.

AU - Lindgren, Cecilia M.

AU - Morris, Andrew P.

AU - Cesarini, David

AU - Johannesson, Magnus

AU - Janson, Eva Tiensuu

AU - Lind, Lars

AU - Pedersen, Nancy L.

AU - Ingelsson, Erik

AU - Forsberg, Lars A.

PY - 2015/1/2

Y1 - 2015/1/2

N2 - Tobacco smoking is a risk factor for numerous disorders, including cancers affecting organs outside the respiratory tract. Epidemiological data suggest that smoking is a greater risk factor for these cancers in males compared with females. This observation, together with the fact that males have a higher incidence of and mortality from most non-sex-specific cancers, remains unexplained. Loss of chromosome Y (LOY) in blood cells is associated with increased risk of nonhematological tumors. We demonstrate here that smoking is associated with LOY in blood cells in three independent cohorts [TwinGene: odds ratio (OR) = 4.3, 95% confidence interval (CI) = 2.8 to 6.7; Uppsala Longitudinal Study of Adult Men: OR = 2.4, 95% CI = 1.6 to 3.6; and Prospective Investigation of the Vasculature in Uppsala Seniors: OR = 3.5, 95% CI = 1.4 to 8.4] encompassing a total of 6014 men. The data also suggest that smoking has a transient and dose-dependent mutagenic effect on LOY status. The finding that smoking induces LOY thus links a preventable risk factor with the most common acquired human mutation.

AB - Tobacco smoking is a risk factor for numerous disorders, including cancers affecting organs outside the respiratory tract. Epidemiological data suggest that smoking is a greater risk factor for these cancers in males compared with females. This observation, together with the fact that males have a higher incidence of and mortality from most non-sex-specific cancers, remains unexplained. Loss of chromosome Y (LOY) in blood cells is associated with increased risk of nonhematological tumors. We demonstrate here that smoking is associated with LOY in blood cells in three independent cohorts [TwinGene: odds ratio (OR) = 4.3, 95% confidence interval (CI) = 2.8 to 6.7; Uppsala Longitudinal Study of Adult Men: OR = 2.4, 95% CI = 1.6 to 3.6; and Prospective Investigation of the Vasculature in Uppsala Seniors: OR = 3.5, 95% CI = 1.4 to 8.4] encompassing a total of 6014 men. The data also suggest that smoking has a transient and dose-dependent mutagenic effect on LOY status. The finding that smoking induces LOY thus links a preventable risk factor with the most common acquired human mutation.

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Smoking is associated with mosaic loss of chromosome Y

Abstract

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