Snap-top nanocarriers

Michael W. Ambrogio, Travis A. Pecorelli, Kaushik Patel, Niveen M. Khashab, Ali Trabolsi, Hussam A. Khatib, Youssry Y. Botros, Jeffrey I. Zink, J. Fraser Stoddart

Research output: Contribution to journalArticlepeer-review


(Equation Presented). An approach to the design and fabrication of mechanized mesoporous silica nanoparticles is demonstrated at the proof of principle level. It relies on the reductive cleavage of disulfide bonds within an integrated nanosystem, wherein surface-bound rotaxanes incorporate disulfide bonds in their stalks,-which are encircled by cucurbit[6]uril or α-cyclodextrin rings, until reductive chemistry is performed, resulting in the snapping of the stalks of the rotaxanes, leading to cargo release from the inside of the nanoparticles.

Original languageEnglish (US)
Pages (from-to)3304-3307
Number of pages4
JournalOrganic Letters
Issue number15
StatePublished - Aug 6 2010

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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