So many pieces, one puzzle: Cell type specification and visual circuitry in flies and mice

Mathias F. Wernet, Andrew D. Huberman, Claude Desplan

Research output: Contribution to journalReview article

Abstract

The visual system is a powerful model for probing the development, connectivity, and function of neural circuits. Two genetically tractable species, mice and flies, are together providing a great deal of understanding of these processes. Current efforts focus on integrating knowledge gained from three cross-fostering fields of research: (1) understanding how the fates of different cell types are specified during development, (2) revealing the synaptic connections between identified cell types (‘‘connectomics’’) by high-resolution three-dimensional circuit anatomy, and (3) causal testing of how identified circuit elements contribute to visual perception and behavior. Here we discuss representative examples from fly and mouse models to illustrate the ongoing success of this tripartite strategy, focusing on the ways it is enhancing our understanding of visual processing and other sensory systems.

Original languageEnglish (US)
Pages (from-to)2565-2584
Number of pages20
JournalGenes and Development
Volume28
Issue number23
DOIs
StatePublished - Dec 1 2014

Keywords

  • Cell types
  • Circuitry
  • Function
  • Vision

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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