Soft tissue differentiation by diffuse reflectance spectroscopy

Azhar Zam, Florian Stelzle, Emeka Nkenke, Katja Tangermann-Gerk, Michael Schmidt, Werner Adler, Alexandre Douplik

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Laser surgery gives the possibility to work remotely which leads to high precision, little trauma and high level sterility. However these advantages are coming with the lack of haptic feedback during the laser ablation of tissue. Therefore additional means are required to control tissue-specific ablation during laser surgery supporting the surgeon regardless of experience and skills. Diffuse Reflectance Spectroscopy provides a straightforward and simple approach for optical tissue differentiation. We measured diffuse reflectance from four various tissue types ex vivo. We applied Linear Discriminant Analysis (LDA) to differentiate the four tissue types and computed the area under the ROC curve (AUC). Special emphasis was taken on the identification of nerve as the most crucial tissue for maxillofacial surgery. The results show a promise for differentiating soft tissues as guidance for tissue-specific laser surgery by means of the diffuse reflectance.

Original languageEnglish (US)
Title of host publicationClinical and Biomedical Spectroscopy
StatePublished - 2009
EventClinical and Biomedical Spectroscopy - Munich, Germany
Duration: Jun 16 2009Jun 18 2009

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceClinical and Biomedical Spectroscopy


  • Diffuse reflectance
  • Feedback system
  • Laser surgery
  • Linear discriminant analysis
  • Soft tissue
  • Tissue differentiation

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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