Solid-phase synthesis of hydrogen-bond surrogate-derived α-helices

Gianluca Dimartino, Deyun Wang, Ross N. Chapman, Paramjit S. Arora

Research output: Contribution to journalArticlepeer-review


(Chemical Equation Presented) This report describes the solid-phase synthesis of hydrogen-bond surrogate-derived artificial α-helices by a ring-closing metathesis reaction. From a series of metathesis catalysts evaluated for the synthesis of these helices, the Hoveyda-Grubbs catalyst was found to afford high yields of the macrocycle irrespective of the peptide sequence.

Original languageEnglish (US)
Pages (from-to)2389-2392
Number of pages4
JournalOrganic Letters
Issue number12
StatePublished - Jun 9 2005

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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