Abstract
(Chemical Equation Presented) This report describes the solid-phase synthesis of hydrogen-bond surrogate-derived artificial α-helices by a ring-closing metathesis reaction. From a series of metathesis catalysts evaluated for the synthesis of these helices, the Hoveyda-Grubbs catalyst was found to afford high yields of the macrocycle irrespective of the peptide sequence.
Original language | English (US) |
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Pages (from-to) | 2389-2392 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 7 |
Issue number | 12 |
DOIs | |
State | Published - Jun 9 2005 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry