Solution-based analysis of multiple analytes by a sensor array: Toward the development of an `electronic tongue'

Steve Savoy, John J. Lavigne, J. Seung Jin Yoo, John Wright, Marc Rodriguez, Adrian Goodey, Bridget McDoniel, John McDevitt, Eric V. Anslyn, Jason B. Shears, Andrew Ellington, Dean P. Neikirk

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A micromachined sensor array has been developed for the rapid characterization of multi-component mixtures in aqueous media. The sensor functions in a manner analogous to that of the mammalian tongue, using an array composed of individually immobilized polystyrene-polyethylene glycol composite microspheres selectively arranged in micromachined etch cavities localized on silicon wafers. Sensing occurs via colorimetric or fluorometric changes to indicator molecules that are covalently bound to amine termination sites on the polymeric microspheres. The hybrid micromachined structure has been interfaced directly to a charged-coupled-device (CCD) that is used for the simultaneous acquisition of the optical data from the individually addressable `taste bud' elements. With the miniature sensor array, acquisition of data streams composed of red, green, and blue (RGB) color patterns distinctive for the analytes in the solution are rapidly acquired. The unique combination of carefully chosen reporter molecules with water permeable microspheres allows for the simultaneous detection and quantification of a variety of analytes. The fabrication of the sensor structure and the initial colorimetric and fluorescent responses for pH, Ca+2, Ce+3, and sugar are reported. Interface to microfluidic components should also be possible, producing a complete sampling/sensing system.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsS. Buttgenbach
PublisherSPIE
Pages17-26
Number of pages10
Volume3539
StatePublished - 1998
EventProceedings of the 1998 Conference on Chemical Microsensors and Applications - Boston, MA, USA
Duration: Nov 4 1998Nov 5 1998

Other

OtherProceedings of the 1998 Conference on Chemical Microsensors and Applications
CityBoston, MA, USA
Period11/4/9811/5/98

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

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