Spatial clustering of hemorrhages in probable cerebral amyloid angiopathy

Jonathan Rosand, Alona Muzikansky, Ashok Kumar, Jonathan J. Wisco, Eric E. Smith, Rebecca A. Betensky, Steven M. Greenberg

Research output: Contribution to journalArticle


Cerebral amyloid angiopathy (CAA) is a common cause of symptomatic intracerebral hemorrhage (ICH), as well as small asymptomatic hemorrhage in the elderly. We used gradient-echo MRI to analyze spatial distribution of 321 hemorrhages in 59 patients with probable CAA-related ICH. Hemorrhagic lesions were found preferentially in the temporal (ratio of actual to expected hemorrhages = 1.37) and occipital lobes (ratio = 1.45, p < 0.0001). Within individuals, hemorrhages tended to cluster, regardless of lobe (p < 0.0001). Among subjects followed prospectively for recurrence, clustering of new symptomatic and asymptomatic hemorrhages was observed. These data suggest that regional differences within the brain play a role in the development of CAA-related hemorrhage.

Original languageEnglish (US)
Pages (from-to)459-462
Number of pages4
JournalAnnals of Neurology
Issue number3
StatePublished - Sep 2005

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Rosand, J., Muzikansky, A., Kumar, A., Wisco, J. J., Smith, E. E., Betensky, R. A., & Greenberg, S. M. (2005). Spatial clustering of hemorrhages in probable cerebral amyloid angiopathy. Annals of Neurology, 58(3), 459-462.