Abstract
Advanced cerebrovascular β-amyloid deposition (cerebral amyloid angiopathy, CAA) is associated with cerebral microbleeds, but the precise relationship between CAA burden and microbleeds is undefined. We used T2*-weighted magnetic resonance imaging (MRI) and noninvasive amyloid imaging with Pittsburgh Compound B (PiB) to analyze the spatial relationship between CAA and microbleeds. On coregistered positron emission tomography (PET) and MRI images, PiB retention was increased at microbleed sites compared to simulated control lesions (p = 0.002) and declined with increasing distance from the microbleed (p < 0.0001). These findings indicate that microbleeds occur preferentially in local regions of concentrated amyloid and support therapeutic strategies aimed at reducing vascular amyloid deposition.
Original language | English (US) |
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Pages (from-to) | 545-548 |
Number of pages | 4 |
Journal | Annals of Neurology |
Volume | 68 |
Issue number | 4 |
DOIs | |
State | Published - Oct 2010 |
ASJC Scopus subject areas
- Neurology
- Clinical Neurology