Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy

Gregory A. Dierksen; Maureen E. Skehan; Muhammad A. Khan; Jed Jeng; R. N.Kaveer Nandigam; John A. Becker; Ashok Kumar; Krista L. Neal; Rebecca A. Betensky; Matthew P. Frosch; Jonathan Rosand; Keith A. Johnson; Anand Viswanathan; David H. Salat; Steven M. Greenberg

doi:10.1002/ana.22099

Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy

Gregory A. Dierksen, Maureen E. Skehan, Muhammad A. Khan, Jed Jeng, R. N.Kaveer Nandigam, John A. Becker, Ashok Kumar, Krista L. Neal, Rebecca A. Betensky, Matthew P. Frosch, Jonathan Rosand, Keith A. Johnson, Anand Viswanathan, David H. Salat, Steven M. Greenberg

Global Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

Advanced cerebrovascular β-amyloid deposition (cerebral amyloid angiopathy, CAA) is associated with cerebral microbleeds, but the precise relationship between CAA burden and microbleeds is undefined. We used T2*-weighted magnetic resonance imaging (MRI) and noninvasive amyloid imaging with Pittsburgh Compound B (PiB) to analyze the spatial relationship between CAA and microbleeds. On coregistered positron emission tomography (PET) and MRI images, PiB retention was increased at microbleed sites compared to simulated control lesions (p = 0.002) and declined with increasing distance from the microbleed (p < 0.0001). These findings indicate that microbleeds occur preferentially in local regions of concentrated amyloid and support therapeutic strategies aimed at reducing vascular amyloid deposition.

Original language	English (US)
Pages (from-to)	545-548
Number of pages	4
Journal	Annals of Neurology
Volume	68
Issue number	4
DOIs	https://doi.org/10.1002/ana.22099
State	Published - Oct 2010

ASJC Scopus subject areas

Neurology
Clinical Neurology

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Dierksen, G. A., Skehan, M. E., Khan, M. A., Jeng, J., Nandigam, R. N. K., Becker, J. A., Kumar, A., Neal, K. L., Betensky, R. A., Frosch, M. P., Rosand, J., Johnson, K. A., Viswanathan, A., Salat, D. H., & Greenberg, S. M. (2010). Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy. Annals of Neurology, 68(4), 545-548. https://doi.org/10.1002/ana.22099

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title = "Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy",

abstract = "Advanced cerebrovascular β-amyloid deposition (cerebral amyloid angiopathy, CAA) is associated with cerebral microbleeds, but the precise relationship between CAA burden and microbleeds is undefined. We used T2*-weighted magnetic resonance imaging (MRI) and noninvasive amyloid imaging with Pittsburgh Compound B (PiB) to analyze the spatial relationship between CAA and microbleeds. On coregistered positron emission tomography (PET) and MRI images, PiB retention was increased at microbleed sites compared to simulated control lesions (p = 0.002) and declined with increasing distance from the microbleed (p < 0.0001). These findings indicate that microbleeds occur preferentially in local regions of concentrated amyloid and support therapeutic strategies aimed at reducing vascular amyloid deposition.",

author = "Dierksen, {Gregory A.} and Skehan, {Maureen E.} and Khan, {Muhammad A.} and Jed Jeng and Nandigam, {R. N.Kaveer} and Becker, {John A.} and Ashok Kumar and Neal, {Krista L.} and Betensky, {Rebecca A.} and Frosch, {Matthew P.} and Jonathan Rosand and Johnson, {Keith A.} and Anand Viswanathan and Salat, {David H.} and Greenberg, {Steven M.}",

year = "2010",

month = oct,

doi = "10.1002/ana.22099",

language = "English (US)",

volume = "68",

pages = "545--548",

journal = "Annals of Neurology",

issn = "0364-5134",

publisher = "John Wiley and Sons Inc.",

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T1 - Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy

AU - Dierksen, Gregory A.

AU - Skehan, Maureen E.

AU - Khan, Muhammad A.

AU - Jeng, Jed

AU - Nandigam, R. N.Kaveer

AU - Becker, John A.

AU - Kumar, Ashok

AU - Neal, Krista L.

AU - Betensky, Rebecca A.

AU - Frosch, Matthew P.

AU - Rosand, Jonathan

AU - Johnson, Keith A.

AU - Viswanathan, Anand

AU - Salat, David H.

AU - Greenberg, Steven M.

PY - 2010/10

Y1 - 2010/10

N2 - Advanced cerebrovascular β-amyloid deposition (cerebral amyloid angiopathy, CAA) is associated with cerebral microbleeds, but the precise relationship between CAA burden and microbleeds is undefined. We used T2*-weighted magnetic resonance imaging (MRI) and noninvasive amyloid imaging with Pittsburgh Compound B (PiB) to analyze the spatial relationship between CAA and microbleeds. On coregistered positron emission tomography (PET) and MRI images, PiB retention was increased at microbleed sites compared to simulated control lesions (p = 0.002) and declined with increasing distance from the microbleed (p < 0.0001). These findings indicate that microbleeds occur preferentially in local regions of concentrated amyloid and support therapeutic strategies aimed at reducing vascular amyloid deposition.

AB - Advanced cerebrovascular β-amyloid deposition (cerebral amyloid angiopathy, CAA) is associated with cerebral microbleeds, but the precise relationship between CAA burden and microbleeds is undefined. We used T2*-weighted magnetic resonance imaging (MRI) and noninvasive amyloid imaging with Pittsburgh Compound B (PiB) to analyze the spatial relationship between CAA and microbleeds. On coregistered positron emission tomography (PET) and MRI images, PiB retention was increased at microbleed sites compared to simulated control lesions (p = 0.002) and declined with increasing distance from the microbleed (p < 0.0001). These findings indicate that microbleeds occur preferentially in local regions of concentrated amyloid and support therapeutic strategies aimed at reducing vascular amyloid deposition.

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EP - 548

JO - Annals of Neurology

JF - Annals of Neurology

IS - 4

ER -

Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy

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