Spatial sensitivity profiles by time-resolved fluorescence Monte Carlo simulation

P. Kadimcherla, M. Sadoqi, S. Kumar

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Many investigations in the literature have studied the migration of photons in fluorescent and non-fluorescent applications, both in the steady-state and time-resolved, within a tissue-simulating medium. However, none have addressed the specific issue of quantified the subsequent migration path of the emitted photons. This is important since fluorescent spectroscopy has been gaining acceptance as an important diagnostic tool. In this paper we show the migration patterns of fluorescent photons with respect to time in a scattering medium such as tissue. The images produced are of the paths of the emission photons that reach the detector. We are able to observe how they migrate at different times. We investigate the effect of the absorption and scattering coefficients on the migration patterns, and how it could give us information about methods to detect inhomogeneities in the medium. The images produced give us information about the accuracy of the estimation of the optical properties in particular medium. Finally, we study how the detector position and absorption and scattering coefficients affect the source of the photons that reach the detector. We discover that during the rising time of the temporal spectrum most of the detected fluorescent photons are being generated very close to the source and the path followed by these photons are localized near the detector. Therefore, we could explore this for the best orientation and location of the detector and source positions to locate inhomogenieties and also source of fluorescence photons within the medium.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsB. Chance, R.R. Alfano, B.J. Tromberg, M. Tamura, E.M. Sevick-Muraca
Pages581-590
Number of pages10
Volume4955
DOIs
StatePublished - 2003
EventPROGRESS IN BIOMEDICAL OPTICS AND IMAGING: Optical Tomography and Spectroscopy of Tissue V - San Jose, CA, United States
Duration: Jan 26 2003Jan 29 2003

Other

OtherPROGRESS IN BIOMEDICAL OPTICS AND IMAGING: Optical Tomography and Spectroscopy of Tissue V
CountryUnited States
CitySan Jose, CA
Period1/26/031/29/03

Keywords

  • Absorption coefficient
  • Fluorescence
  • Monte Carlo
  • Optical properties
  • Photon migration
  • Scattering coefficient
  • Simulation
  • Tissue

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

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  • Cite this

    Kadimcherla, P., Sadoqi, M., & Kumar, S. (2003). Spatial sensitivity profiles by time-resolved fluorescence Monte Carlo simulation. In B. Chance, R. R. Alfano, B. J. Tromberg, M. Tamura, & E. M. Sevick-Muraca (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4955, pp. 581-590) https://doi.org/10.1117/12.478179