@inproceedings{93650f7aa1174e5987a3c228f1d7c39c,
title = "Spatiotemporal analysis of structural changes of the lamina cribrosa",
abstract = "Glaucoma, a progressive and degenerative disease of the optic nerve, is the second leading cause of blindness worldwide. Mechanical deformation of the lamina cribrosa (LC) under high intraocular pressure (IOP) can lead to axonal death of optic nerve fibers. To explore the effect of pressure on the LC, we utilize an experimental setup where longitudinal 3D optical coherence tomography (OCT) images are acquired at different levels of IOP administered via a well-controlled external force. Structural changes are measured via image deformations which map all observed images simultaneously into a common coordinate space. These deformations encode local patterns of structural and volume change across the image sequence, resulting in quantification of the spatiotemporal deformation pattern of the LC due to variation of pressure. We also describe a 3D segmentation algorithm to restrict our deformation analysis separately to the beams or pores of the LC. A single case study demonstrates the potential of the proposed methodology for non-invasive in-vivo analysis of LC dynamics in individual subjects.",
keywords = "Glaucoma, Lamina cribrosa, OCT, Spatiotemporal analysis",
author = "Charly Girot and Hiroshi Ishikawa and James Fishbaugh and Gadi Wollstein and Joel Schuman and Guido Gerig",
year = "2017",
doi = "10.1007/978-3-319-67561-9_21",
language = "English (US)",
isbn = "9783319675602",
series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",
publisher = "Springer Verlag",
pages = "185--193",
editor = "Cardoso, {M. Jorge} and Tal Arbel",
booktitle = "Fetal, Infant and Ophthalmic Medical Image Analysis - International Workshop, FIFI 2017 and 4th International Workshop, OMIA 2017 Held in Conjunction with MICCAI 2017, Proceedings",
note = "International Workshop on Fetal and Infant Image Analysis, FIFI 2017 and 4th International Workshop on Ophthalmic Medical Image Analysis, OMIA 2017 held in Conjunction with 20th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2017 ; Conference date: 14-09-2017 Through 14-09-2017",
}