Spatiotemporal analysis of structural changes of the lamina cribrosa

Charly Girot, Hiroshi Ishikawa, James Fishbaugh, Gadi Wollstein, Joel Schuman, Guido Gerig

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Glaucoma, a progressive and degenerative disease of the optic nerve, is the second leading cause of blindness worldwide. Mechanical deformation of the lamina cribrosa (LC) under high intraocular pressure (IOP) can lead to axonal death of optic nerve fibers. To explore the effect of pressure on the LC, we utilize an experimental setup where longitudinal 3D optical coherence tomography (OCT) images are acquired at different levels of IOP administered via a well-controlled external force. Structural changes are measured via image deformations which map all observed images simultaneously into a common coordinate space. These deformations encode local patterns of structural and volume change across the image sequence, resulting in quantification of the spatiotemporal deformation pattern of the LC due to variation of pressure. We also describe a 3D segmentation algorithm to restrict our deformation analysis separately to the beams or pores of the LC. A single case study demonstrates the potential of the proposed methodology for non-invasive in-vivo analysis of LC dynamics in individual subjects.

Original languageEnglish (US)
Title of host publicationFetal, Infant and Ophthalmic Medical Image Analysis - International Workshop, FIFI 2017 and 4th International Workshop, OMIA 2017 Held in Conjunction with MICCAI 2017, Proceedings
EditorsM. Jorge Cardoso, Tal Arbel
PublisherSpringer Verlag
Pages185-193
Number of pages9
ISBN (Print)9783319675602
DOIs
StatePublished - 2017
EventInternational Workshop on Fetal and Infant Image Analysis, FIFI 2017 and 4th International Workshop on Ophthalmic Medical Image Analysis, OMIA 2017 held in Conjunction with 20th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2017 - Quebec City, Canada
Duration: Sep 14 2017Sep 14 2017

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume10554 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

OtherInternational Workshop on Fetal and Infant Image Analysis, FIFI 2017 and 4th International Workshop on Ophthalmic Medical Image Analysis, OMIA 2017 held in Conjunction with 20th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2017
Country/TerritoryCanada
CityQuebec City
Period9/14/179/14/17

Keywords

  • Glaucoma
  • Lamina cribrosa
  • OCT
  • Spatiotemporal analysis

ASJC Scopus subject areas

  • Theoretical Computer Science
  • General Computer Science

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