Spatiotemporal atlas estimation for developmental delay detection in longitudinal datasets

Stanley Durrleman, Xavier Pennec, Alain Trouvé, Guido Gerig, Nicholas Ayache

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We propose a new methodology to analyze the anatomical variability of a set of longitudinal data (population scanned at several ages). This method accounts not only for the usual 3D anatomical variability (geometry of structures), but also for possible changes in the dynamics of evolution of the structures. It does not require that subjects are scanned the same number of times or at the same ages. First a regression model infers a continuous evolution of shapes from a set of observations of the same subject. Second, spatiotemporal registrations deform jointly (1) the geometry of the evolving structure via 3D deformations and (2) the dynamics of evolution via time change functions. Third, we infer from a population a prototype scenario of evolution and its 4D variability. Our method is used to analyze the morphological evolution of 2D profiles of hominids skulls and to analyze brain growth from amygdala of autistics, developmental delay and control children.

Original languageEnglish (US)
Title of host publicationMedical Image Computing and Computer-Assisted Intervention - MICCAI 2009 - 12th International Conference, Proceedings
PublisherSpringer Verlag
Pages297-304
Number of pages8
EditionPART 1
ISBN (Print)3642042678, 9783642042676
DOIs
StatePublished - 2009
Event12th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2009 - London, United Kingdom
Duration: Sep 20 2009Sep 24 2009

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
NumberPART 1
Volume5761 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other12th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2009
Country/TerritoryUnited Kingdom
CityLondon
Period9/20/099/24/09

ASJC Scopus subject areas

  • Theoretical Computer Science
  • General Computer Science

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