Speckle reduction in visible-light optical coherence tomography using scan modulation

Ian Rubinoff; Lisa Beckmann; Yuanbo Wang; Amani A. Fawzi; Xiaorong Liu; Jenna Tauber; Katie Jones; Hiroshi Ishikawa; Joel S. Schuman; Roman Kuranov; Hao F. Zhang

doi:10.1117/1.NPh.6.4.041107

Speckle reduction in visible-light optical coherence tomography using scan modulation

Ian Rubinoff, Lisa Beckmann, Yuanbo Wang, Amani A. Fawzi, Xiaorong Liu, Jenna Tauber, Katie Jones, Hiroshi Ishikawa, Joel S. Schuman, Roman Kuranov, Hao F. Zhang

Research output: Contribution to journal › Article › peer-review

Abstract

We present a technique to reduce speckle in visible-light optical coherence tomography (vis-OCT) that preserves fine structural details and is robust against sample motion. Specifically, we locally modulate B-scans orthogonally to their axis of acquisition. Such modulation enables acquisition of uncorrelated speckle patterns from similar anatomical locations, which can be averaged to reduce speckle. To verify the effectiveness of speckle reduction, we performed in-vivo retinal imaging using modulated raster and circular scans in both mice and humans. We compared speckle-reduced vis-OCT images with the images acquired with unmodulated B-scans from the same anatomical locations. We compared contrast-to-noise ratio (CNR) and equivalent number of looks (ENL) to quantify the image quality enhancement. Speckle-reduced images showed up to a 2.35-dB improvement in CNR and up to a 3.1-fold improvement in ENL with more discernable anatomical features using eight modulated A-line averages at a 25-kHz A-line rate.

Original language	English (US)
Article number	041107
Journal	Neurophotonics
Volume	6
Issue number	4
DOIs	https://doi.org/10.1117/1.NPh.6.4.041107
State	Published - Oct 1 2019

Keywords

clinic
imaging
optical coherence tomography
retina
speckle
visible light

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging

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10.1117/1.NPh.6.4.041107

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Speckle reduction in visible-light optical coherence tomography using scan modulation. / Rubinoff, Ian; Beckmann, Lisa; Wang, Yuanbo; Fawzi, Amani A.; Liu, Xiaorong; Tauber, Jenna; Jones, Katie; Ishikawa, Hiroshi; Schuman, Joel S.; Kuranov, Roman; Zhang, Hao F.

In: Neurophotonics, Vol. 6, No. 4, 041107, 01.10.2019.

Research output: Contribution to journal › Article › peer-review

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title = "Speckle reduction in visible-light optical coherence tomography using scan modulation",

abstract = "We present a technique to reduce speckle in visible-light optical coherence tomography (vis-OCT) that preserves fine structural details and is robust against sample motion. Specifically, we locally modulate B-scans orthogonally to their axis of acquisition. Such modulation enables acquisition of uncorrelated speckle patterns from similar anatomical locations, which can be averaged to reduce speckle. To verify the effectiveness of speckle reduction, we performed in-vivo retinal imaging using modulated raster and circular scans in both mice and humans. We compared speckle-reduced vis-OCT images with the images acquired with unmodulated B-scans from the same anatomical locations. We compared contrast-to-noise ratio (CNR) and equivalent number of looks (ENL) to quantify the image quality enhancement. Speckle-reduced images showed up to a 2.35-dB improvement in CNR and up to a 3.1-fold improvement in ENL with more discernable anatomical features using eight modulated A-line averages at a 25-kHz A-line rate.",

keywords = "clinic, imaging, optical coherence tomography, retina, speckle, visible light",

author = "Ian Rubinoff and Lisa Beckmann and Yuanbo Wang and Fawzi, {Amani A.} and Xiaorong Liu and Jenna Tauber and Katie Jones and Hiroshi Ishikawa and Schuman, {Joel S.} and Roman Kuranov and Zhang, {Hao F.}",

note = "Funding Information: This work was supported in part by NIH Grants Nos. R01EY026078, DP3DK108248, R01EY029121, R01EY028304, R44EY026466, and T32EY25202. L.B. was supported by the NSF Graduate Research Fellowship 1000260620. The authors would like to thank David Miller and Rozita Ghassabi for their helpful discussions. Funding Information: This work was supported in part by NIH Grants Nos. R01EY026078, DP3DK108248, R01EY029121, R01EY028304, R44EY026466, and T32EY25202. L.B. was supported by the NSF Graduate Research Fellowship 1000260620. Publisher Copyright: {\textcopyright} 2019 The Authors.",

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AU - Rubinoff, Ian

AU - Beckmann, Lisa

AU - Wang, Yuanbo

AU - Fawzi, Amani A.

AU - Liu, Xiaorong

AU - Tauber, Jenna

AU - Jones, Katie

AU - Ishikawa, Hiroshi

AU - Schuman, Joel S.

AU - Kuranov, Roman

AU - Zhang, Hao F.

N1 - Funding Information: This work was supported in part by NIH Grants Nos. R01EY026078, DP3DK108248, R01EY029121, R01EY028304, R44EY026466, and T32EY25202. L.B. was supported by the NSF Graduate Research Fellowship 1000260620. The authors would like to thank David Miller and Rozita Ghassabi for their helpful discussions. Funding Information: This work was supported in part by NIH Grants Nos. R01EY026078, DP3DK108248, R01EY029121, R01EY028304, R44EY026466, and T32EY25202. L.B. was supported by the NSF Graduate Research Fellowship 1000260620. Publisher Copyright: © 2019 The Authors.

PY - 2019/10/1

Y1 - 2019/10/1

N2 - We present a technique to reduce speckle in visible-light optical coherence tomography (vis-OCT) that preserves fine structural details and is robust against sample motion. Specifically, we locally modulate B-scans orthogonally to their axis of acquisition. Such modulation enables acquisition of uncorrelated speckle patterns from similar anatomical locations, which can be averaged to reduce speckle. To verify the effectiveness of speckle reduction, we performed in-vivo retinal imaging using modulated raster and circular scans in both mice and humans. We compared speckle-reduced vis-OCT images with the images acquired with unmodulated B-scans from the same anatomical locations. We compared contrast-to-noise ratio (CNR) and equivalent number of looks (ENL) to quantify the image quality enhancement. Speckle-reduced images showed up to a 2.35-dB improvement in CNR and up to a 3.1-fold improvement in ENL with more discernable anatomical features using eight modulated A-line averages at a 25-kHz A-line rate.

AB - We present a technique to reduce speckle in visible-light optical coherence tomography (vis-OCT) that preserves fine structural details and is robust against sample motion. Specifically, we locally modulate B-scans orthogonally to their axis of acquisition. Such modulation enables acquisition of uncorrelated speckle patterns from similar anatomical locations, which can be averaged to reduce speckle. To verify the effectiveness of speckle reduction, we performed in-vivo retinal imaging using modulated raster and circular scans in both mice and humans. We compared speckle-reduced vis-OCT images with the images acquired with unmodulated B-scans from the same anatomical locations. We compared contrast-to-noise ratio (CNR) and equivalent number of looks (ENL) to quantify the image quality enhancement. Speckle-reduced images showed up to a 2.35-dB improvement in CNR and up to a 3.1-fold improvement in ENL with more discernable anatomical features using eight modulated A-line averages at a 25-kHz A-line rate.

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Speckle reduction in visible-light optical coherence tomography using scan modulation

Abstract

Keywords

ASJC Scopus subject areas

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