Spectral oximetry assessed with high-speed ultra-highresolution optical coherence tomography

Larry Kagemann, Gadi Wollstein, Maciej Wojtkowski, Hiroshi Ishikawa, Kelly A. Townsend, Michelle L. Gabriele, Vivek J. Srinivasan, James G. Fujimoto, Joel S. Schuman

    Research output: Contribution to journalArticlepeer-review

    Abstract

    We use Fourier domain optical coherence tomography (OCT) data to assess retinal blood oxygen saturation. Three-dimensional disk-centered retinal tissue volumes were assessed in 17 normal healthy subjects. After removing DC and low-frequency a-scan components, an OCT fundus image was created by integrating total reflectance into a single reflectance value. Thirty fringe patterns were sampled; 10 each from the edge of an artery, adjacent tissue, and the edge of a vein, respectively. A-scans were recalculated, zeroing the DC term in the power spectrum, and used for analysis. Optical density ratios (ODRs) were calculated as ODRArt =ln(Tissue855/ Art855) / ln(Tissue805/ Art805) and ODRVein =ln(Tissue855/Vein855) / ln(Tissue805/Vein805) with Tissue, Art, and Vein representing total a-scan reflectance at the 805- or 855-nm centered bandwidth. Arterial and venous ODRs were compared by the Wilcoxon signed rank test. Arterial ODRs were significantly greater than venous ODRs (1.007±2.611 and -1.434±4.310, respectively; p=0.0217) (mean±standard deviation). A difference between arterial and venous blood saturation was detected. This suggests that retinal oximetry may possibly be added as a metabolic measurement in structural imaging devices.

    Original languageEnglish (US)
    Article number041212
    JournalJournal of biomedical optics
    Volume12
    Issue number4
    DOIs
    StatePublished - Jul 2007

    Keywords

    • Metabolism
    • Optical coherence tomography
    • Oximetry
    • Oxygen
    • Retina
    • Spectroscopy

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Biomaterials
    • Atomic and Molecular Physics, and Optics
    • Biomedical Engineering

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