Spine calcium signaling

Adam Carter, Bernardo Sabatini

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Spines are specialized cellular compartments found at high density on the dendrites of many neurons. Glutamatergic synapses are made onto spines, which house much of the local machinery necessary to readout and regulate synaptic activity. By providing a diffusionally isolated signaling compartment, spines allow neighboring synapses to operate independently. Stimulusevoked increases in calcium concentration within spines trigger many forms of synaptic plasticity and can influence local excitability and morphology. This chapter focuses on the mechanisms of calcium handling and signaling within individual spines.

Original languageEnglish (US)
Title of host publicationDendrites
PublisherOxford University Press
ISBN (Electronic)9780191724206
ISBN (Print)9780198566564
DOIs
StatePublished - Mar 22 2012

Keywords

  • Calcium concentration
  • Calcium signaling
  • Cellular compartments
  • Glutamatergic synapses
  • Synaptic activity
  • Synaptic plasticity

ASJC Scopus subject areas

  • Neuroscience(all)

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