Spore germination: Two ion channels are better than one

Research output: Contribution to journalReview articlepeer-review


Germination is the process by which spores emerge from dormancy. Although spores can remain dormant for decades, the study of germination is an active field of research. In this issue of Genes & Development, Gao and colleagues (pp. 31-45) address a perplexing question: How can a dormant spore initiate germination in response to environmental cues? Three distinct complexes are involved: GerA, a germinant-gated ion channel; 5AF/FigP, a second ion channel required for amplification; and SpoVA, a channel for dipicolinic acid (DPA). DPA release is followed by rehydration of the spore core, thus allowing the resumption of metabolic activity.

Original languageEnglish (US)
Pages (from-to)1-3
Number of pages3
JournalGenes & development
Issue number1-2
StatePublished - Feb 13 2024


  • dormancy
  • GerA
  • germination
  • ion channel
  • signal transduction
  • sporulation

ASJC Scopus subject areas

  • General Medicine


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