Statistical growth modeling of longitudinal DT-MRI for regional characterization of early brain development

Neda Sadeghi, Marcel Prastawa, P. Thomas Fletcher, John H. Gilmore, Weili Lin, Guido Gerig

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    A population growth model that represents the growth trajectories of individual subjects is critical to study and understand neurodevelopment. This paper presents a framework for jointly estimating and modeling individual and population growth trajectories, and determining significant regional differences in growth pattern characteristics applied to longitudinal neuroimaging data. We use non-linear mixed effect modeling where temporal change is modeled by the Gompertz function. The Gompertz function uses intuitive parameters related to delay, rate of change, and expected asymptotic value; all descriptive measures which can answer clinical questions related to growth. Our proposed framework combines nonlinear modeling of individual trajectories, population analysis, and testing for regional differences. We apply this framework to the study of early maturation in white matter regions as measured with diffusion tensor imaging (DTI). Regional differences between anatomical regions of interest that are known to mature differently are analyzed and quantified. Experiments with image data from a large ongoing clinical study show that our framework provides descriptive, quantitative information on growth trajectories that can be directly interpreted by clinicians. To our knowledge, this is the first longitudinal analysis of growth functions to explain the trajectory of early brain maturation as it is represented in DTI.

    Original languageEnglish (US)
    Title of host publication2012 9th IEEE International Symposium on Biomedical Imaging
    Subtitle of host publicationFrom Nano to Macro, ISBI 2012 - Proceedings
    Pages1507-1510
    Number of pages4
    DOIs
    StatePublished - 2012
    Event2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012 - Barcelona, Spain
    Duration: May 2 2012May 5 2012

    Publication series

    NameProceedings - International Symposium on Biomedical Imaging
    ISSN (Print)1945-7928
    ISSN (Electronic)1945-8452

    Other

    Other2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012
    CountrySpain
    CityBarcelona
    Period5/2/125/5/12

    ASJC Scopus subject areas

    • Biomedical Engineering
    • Radiology Nuclear Medicine and imaging

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