Stereodivergent Carbon-Carbon Bond-Forming Reactions

Research output: Contribution to journalShort surveypeer-review


Stereodivergent catalysis has emerged as a compelling strategy for achieving stereochemical diversity in small-molecule library design and natural product synthesis. In this short review, key examples of pioneering catalytic carbon carbon bond-forming transformations that provide access to all stereoisomers of a given product are presented. Current trends and future directions in the field are discussed, highlighting ongoing initiatives to enhance the efficiency and broaden the scope of stereodivergent methodologies. 1 Introduction 2 Mono-catalysis 2.1 Change of Reaction Conditions 2.2 Change of Catalyst 3 Multi-catalysis 3.1 Bifunctional Catalysis 3.2 Sequential/Cascade Catalysis 3.3 Synergistic/Cooperative Catalysis 4 Conclusions and Outlook.

Original languageEnglish (US)
JournalSynthesis (Germany)
StateAccepted/In press - 2023


  • aldol reaction
  • carbon-carbon bond
  • dual catalysis
  • privileged catalysts
  • sequential catalysis
  • stereodivergent synthesis

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry


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