Stereoselective Covalent Binding of Enantiomers of anti-Benzo[a]pyrene Diol Epoxide to DNA As Probed by Optical Detection of Magnetic Resonance

Vassily Kolubayev, Henry C. Brenner, Nicholas E. Geacintov

Research output: Contribution to journalArticle

Abstract

Phosphorescence and optical detection of magnetic resonance measurements applied to the covalent adducts of (+)- and (-)-anti-benzo[a]pyrene with DNA show a marked red shift of the pyrenyl phosphorescence and a lowering of the zero field splitting parameters of the (-) adduct, relative to the (+) adduct and the (solvent-exposed) benzo[a]pyrene tetraol. These results are consistent with a predominance of quasi-intercalative sites in the (-) adduct and external, solvent-exposed sites in the (+) adduct.

Original languageEnglish (US)
Pages (from-to)2638-2641
Number of pages4
JournalBiochemistry
Volume26
Issue number9
DOIs
StatePublished - Jan 1 1987

ASJC Scopus subject areas

  • Biochemistry

Fingerprint Dive into the research topics of 'Stereoselective Covalent Binding of Enantiomers of anti-Benzo[a]pyrene Diol Epoxide to DNA As Probed by Optical Detection of Magnetic Resonance'. Together they form a unique fingerprint.

  • Cite this