Abstract
Squalamine dessulfate (24R) and the unnatural product squalamine dessulfate (24S) have been synthesized from stigmasterol. The key step in establishing the C24 stereochemistry is attachment of the side-chain at C22 using either (2R)- or (2S)-1,2-epoxy-3-methylbutane to yield the cholesteryl precursors of the epimeric squalamine dessulfates.
Original language | English (US) |
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Pages (from-to) | 5139-5142 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 36 |
Issue number | 29 |
State | Published - 1995 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry