Abstract
Squalamine dessulfate (24R) and the unnatural product squalamine dessulfate (24S) have been synthesized from stigmasterol. The key step in establishing the C24 stereochemistry is attachment of the sidechain at C22 using either (2R)- or (2S)-1,2-epoxy-3-methylbutane to yield the cholesteryl precursors of the epimeric squalamine dessulfates.
Original language | English (US) |
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Pages (from-to) | 5139-5142 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 36 |
Issue number | 29 |
DOIs | |
State | Published - Jul 17 1995 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry