Stereoselective synthesis of substituted γ-butyrolactones by the [3 + 2] annulation of allylic silanes with chlorosulfonyl isocyanate: Enantioselective total synthesis of (+)-blastmycinone

Zhi Hui Peng, K. A. Woerpel

Research output: Contribution to journalArticle

Abstract

Equation presented (+)-blastmycinone A stereoselective synthesis of γ-butyrolactones by the [3 + 2] annulation of allylic silanes with N-chlorosulfonyl isocyanate (CSI) was developed. An enantioselective total synthesis of (+)-blastmycinone was accomplished using this annulation as the key step.

Original languageEnglish (US)
Pages (from-to)675-678
Number of pages4
JournalOrganic Letters
Volume3
Issue number5
DOIs
StatePublished - Mar 8 2001

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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