Stereoselective total syntheses of herbicidin C and aureonuclemycin through late-stage glycosylation

Dominik Hager; Peter Mayer; Christian Paulitz; Jörg Tiebes; Dirk Trauner

doi:10.1002/anie.201201826

Stereoselective total syntheses of herbicidin C and aureonuclemycin through late-stage glycosylation

Dominik Hager, Peter Mayer, Christian Paulitz, Jörg Tiebes, Dirk Trauner

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Better late than never! Two herbicidins, members of an important family of nucleoside antibiotics, have been synthesized for the first time. The route integrates a stereoselective C-glycosylation with several reagent-controlled stereoselective transformations and a surprisingly facile and highly diastereoselective late-stage N-glycosylation.

Original language	English (US)
Pages (from-to)	6525-6528
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	26
DOIs	https://doi.org/10.1002/anie.201201826
State	Published - Jun 25 2012

Keywords

antibiotics
glycosylation
nucleosides
stereoselective synthesis
total synthesis

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.201201826

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AU - Tiebes, Jörg

AU - Trauner, Dirk

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KW - glycosylation

KW - nucleosides

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KW - total synthesis

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Stereoselective total syntheses of herbicidin C and aureonuclemycin through late-stage glycosylation

Abstract

Keywords

ASJC Scopus subject areas

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