Stimulation of astroglial 5-HT1A receptors releases the serotonergic growth factor, protein S-100, and alters astroglial morphology

Patricia M. Whitaker-Azmitia; Randall Murphy; Efrain C. Azmitia

doi:10.1016/0006-8993(90)90210-3

Stimulation of astroglial 5-HT_1A receptors releases the serotonergic growth factor, protein S-100, and alters astroglial morphology

Patricia M. Whitaker-Azmitia, Randall Murphy, Efrain C. Azmitia

Biology and Genomics

Research output: Contribution to journal › Article › peer-review

Abstract

Stimulation of astroglial 5-HT_1A receptors causes astroglial cells to acquire a more mature morphology and to release a factor (or factors) which promotes growth of serotonergic neurons. By using an antibody-blocking approach, we have shown that at least one of the growth-promoting factors thus released is the astroglial-specific protein S-100. This may be a particularly important observation, in view of studies implicating S-100 in both Down's syndrome and Alzheimer's disease.

Original language	English (US)
Pages (from-to)	155-158
Number of pages	4
Journal	Brain Research
Volume	528
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(90)90210-3
State	Published - Sep 24 1990

Keywords

Alzheimer's disease
Astroglial growth factor
Down's syndrome
Neuronal growth
S-100
Serotonin
Serotonin-1A receptor

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/0006-8993(90)90210-3

Cite this

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title = "Stimulation of astroglial 5-HT1A receptors releases the serotonergic growth factor, protein S-100, and alters astroglial morphology",

abstract = "Stimulation of astroglial 5-HT1A receptors causes astroglial cells to acquire a more mature morphology and to release a factor (or factors) which promotes growth of serotonergic neurons. By using an antibody-blocking approach, we have shown that at least one of the growth-promoting factors thus released is the astroglial-specific protein S-100. This may be a particularly important observation, in view of studies implicating S-100 in both Down's syndrome and Alzheimer's disease.",

keywords = "Alzheimer's disease, Astroglial growth factor, Down's syndrome, Neuronal growth, S-100, Serotonin, Serotonin-1A receptor",

author = "Whitaker-Azmitia, {Patricia M.} and Randall Murphy and Azmitia, {Efrain C.}",

note = "Funding Information: This work was supported by grants from the National Institute of Neurologial Disease and Stroke to PMW-A and from the National Science Foundation to ECA.",

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T1 - Stimulation of astroglial 5-HT1A receptors releases the serotonergic growth factor, protein S-100, and alters astroglial morphology

AU - Whitaker-Azmitia, Patricia M.

AU - Murphy, Randall

AU - Azmitia, Efrain C.

N1 - Funding Information: This work was supported by grants from the National Institute of Neurologial Disease and Stroke to PMW-A and from the National Science Foundation to ECA.

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Y1 - 1990/9/24

N2 - Stimulation of astroglial 5-HT1A receptors causes astroglial cells to acquire a more mature morphology and to release a factor (or factors) which promotes growth of serotonergic neurons. By using an antibody-blocking approach, we have shown that at least one of the growth-promoting factors thus released is the astroglial-specific protein S-100. This may be a particularly important observation, in view of studies implicating S-100 in both Down's syndrome and Alzheimer's disease.

AB - Stimulation of astroglial 5-HT1A receptors causes astroglial cells to acquire a more mature morphology and to release a factor (or factors) which promotes growth of serotonergic neurons. By using an antibody-blocking approach, we have shown that at least one of the growth-promoting factors thus released is the astroglial-specific protein S-100. This may be a particularly important observation, in view of studies implicating S-100 in both Down's syndrome and Alzheimer's disease.

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KW - Astroglial growth factor

KW - Down's syndrome

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KW - S-100

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