Stimulation of astroglial 5-HT1A receptors releases the serotonergic growth factor, protein S-100, and alters astroglial morphology

Patricia M. Whitaker-Azmitia, Randall Murphy, Efrain C. Azmitia

Research output: Contribution to journalArticle

Abstract

Stimulation of astroglial 5-HT1A receptors causes astroglial cells to acquire a more mature morphology and to release a factor (or factors) which promotes growth of serotonergic neurons. By using an antibody-blocking approach, we have shown that at least one of the growth-promoting factors thus released is the astroglial-specific protein S-100. This may be a particularly important observation, in view of studies implicating S-100 in both Down's syndrome and Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)155-158
Number of pages4
JournalBrain Research
Volume528
Issue number1
DOIs
StatePublished - Sep 24 1990

Keywords

  • Alzheimer's disease
  • Astroglial growth factor
  • Down's syndrome
  • Neuronal growth
  • S-100
  • Serotonin
  • Serotonin-1A receptor

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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