Stimulation of dna synthesis in mouse pancreas by tiriiodothyronine and glucagon

D. Malamud; L. Perrin

doi:10.1210/endo-94-4-1157

Stimulation of dna synthesis in mouse pancreas by tiriiodothyronine and glucagon

D. Malamud, L. Perrin

Research output: Contribution to journal › Article › peer-review

Abstract

An injection of triiodothyronine and glucagon stimulates the growth of several mouse tissues. The greatest increase in DNA specific activity occurred in the cells of the exocrine pancreas after a lag period of about 30 hr. There was also an increase in cell proliferation in the liver. Cellular hypertrophy, as measured by the ratio of RNA to DNA was increased in liver and kidney. This system should prove to be particularly useful for studying the factors controlling pancreatic growth.

Original language	English (US)
Pages (from-to)	1157-1160
Number of pages	4
Journal	Endocrinology
Volume	94
Issue number	4
DOIs	https://doi.org/10.1210/endo-94-4-1157
State	Published - Apr 1974

ASJC Scopus subject areas

Endocrinology

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abstract = "An injection of triiodothyronine and glucagon stimulates the growth of several mouse tissues. The greatest increase in DNA specific activity occurred in the cells of the exocrine pancreas after a lag period of about 30 hr. There was also an increase in cell proliferation in the liver. Cellular hypertrophy, as measured by the ratio of RNA to DNA was increased in liver and kidney. This system should prove to be particularly useful for studying the factors controlling pancreatic growth.",

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Stimulation of dna synthesis in mouse pancreas by tiriiodothyronine and glucagon

Abstract

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