Stimulation of plasminogen activator in osteoblast-like cells by bone-resorbing hormones

J. A. Hamilton; S. R. Lingelbach; N. C. Partridge; T. J. Martin

doi:10.1016/0006-291X(84)90464-9

Stimulation of plasminogen activator in osteoblast-like cells by bone-resorbing hormones

J. A. Hamilton, S. R. Lingelbach, N. C. Partridge, T. J. Martin

Molecular Pathobiology

Research output: Contribution to journal › Article › peer-review

Abstract

Hormonal control of plasminogen activator (PA) was studied in clonal rat osteogenic sarcoma cells which are phenotypically osteoblast, and in osteoblast-rich rat bone cell cultures. The bone-resorbing hormones (parathyroid hormone, prostaglandin E₂, epidermal growth factor and 1,25-dihydroxyvitamin D₃) stimulated PA activity in both cell types. The relative efficacies of vitamin D metabolites and of prostanoids reflect their relative potencies as stimulators of bone resorption.

Original language	English (US)
Pages (from-to)	230-236
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	122
Issue number	1
DOIs	https://doi.org/10.1016/0006-291X(84)90464-9
State	Published - Jul 18 1984

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/0006-291X(84)90464-9

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abstract = "Hormonal control of plasminogen activator (PA) was studied in clonal rat osteogenic sarcoma cells which are phenotypically osteoblast, and in osteoblast-rich rat bone cell cultures. The bone-resorbing hormones (parathyroid hormone, prostaglandin E2, epidermal growth factor and 1,25-dihydroxyvitamin D3) stimulated PA activity in both cell types. The relative efficacies of vitamin D metabolites and of prostanoids reflect their relative potencies as stimulators of bone resorption.",

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AU - Martin, T. J.

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AB - Hormonal control of plasminogen activator (PA) was studied in clonal rat osteogenic sarcoma cells which are phenotypically osteoblast, and in osteoblast-rich rat bone cell cultures. The bone-resorbing hormones (parathyroid hormone, prostaglandin E2, epidermal growth factor and 1,25-dihydroxyvitamin D3) stimulated PA activity in both cell types. The relative efficacies of vitamin D metabolites and of prostanoids reflect their relative potencies as stimulators of bone resorption.

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Stimulation of plasminogen activator in osteoblast-like cells by bone-resorbing hormones

Abstract

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