Stochastic mechanisms of cell fate specification that yield random or robust outcomes

Robert J. Johnston, Claude Desplan

Research output: Contribution to journalReview articlepeer-review


Although cell fate specification is tightly controlled to yield highly reproducible results and avoid extreme variation, developmental programs often incorporate stochastic mechanisms to diversify cell types. Stochastic specification phenomena are observed in a wide range of species and an assorted set of developmental contexts. In bacteria, stochastic mechanisms are utilized to generate transient subpopulations capable of surviving adverse environmental conditions. In vertebrate, insect, and worm nervous systems, stochastic fate choices are used to increase the repertoire of sensory and motor neuron subtypes. Random fate choices are also integrated into developmental programs controlling organogenesis. Although stochastic decisions can be maintained to produce a mosaic of fates within a population of cells, they can also be compensated for or directed to yield robust and reproducible outcomes.

Original languageEnglish (US)
Pages (from-to)689-719
Number of pages31
JournalAnnual Review of Cell and Developmental Biology
StatePublished - Nov 10 2010


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ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology


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