Storage of spatial information by the maintenance mechanism of LTP

Eva Pastalkova, Peter Serrano, Deana Pinkhasova, Emma Wallace, André Antonio Fenton, Todd Charlton Sacktor

Research output: Contribution to journalArticle

Abstract

Analogous to learning and memory storage, long-term potentiation (LTP) is divided into induction and maintenance phases. Testing the hypothesis that the mechanism of LTP maintenance stores information requires reversing this mechanism in vivo and finding out whether long-term stored information is lost. This was not previously possible. Recently however, persistent phosphorylation by the atypical protein kinase C isoform, protein kinase Mzeta (PKMζ), has been found to maintain late LTP in hippocampal slices. Here we show that a cell-permeable PKMζ inhibitor, injected in the rat hippocampus, both reverses LTP maintenance in vivo and produces persistent loss of 1-day-old spatial information. Thus, the mechanism maintaining LTP sustains spatial memory.

Original languageEnglish (US)
Pages (from-to)1141-1444
Number of pages304
JournalScience
Volume313
Issue number5790
DOIs
StatePublished - Aug 25 2006

ASJC Scopus subject areas

  • General

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    Pastalkova, E., Serrano, P., Pinkhasova, D., Wallace, E., Fenton, A. A., & Sacktor, T. C. (2006). Storage of spatial information by the maintenance mechanism of LTP. Science, 313(5790), 1141-1444. https://doi.org/10.1126/science.1128657