Strain difference in fear between spontaneously hypertensive and normotensive rats is mediated by adrenal cortical hormones

Akira Sakaguchi, Joseph E. LeDoux, Alan F. Sved, Donald J. Reis

Research output: Contribution to journalArticle

Abstract

In the present study we sought to determine whether the strain difference in fear reactivity between spontaneously hypertensive rats (SHR) and strain-matched WKY controls might be related to adrenocortical function. SHR and WKY were subjected to adrenalectomy prior to classical fear conditioning. Adrenal cortical steroids were replaced in some animals. Adrenalectomy produced comparable effects on conditioned fear reactivity in SHR and WKY and steroid replacement reversed the effects of adrenalectomy in both strains. However, a larger dose was required to compensate for adrenalectomy in SHR. These date implicate functions related, directly or indirectly, to the adrenal cortex, in the maintenance of the strain difference in fear reactivity.

Original languageEnglish (US)
Pages (from-to)59-64
Number of pages6
JournalNeuroscience letters
Volume46
Issue number1
DOIs
StatePublished - Apr 20 1984

Keywords

  • adrenal cortex
  • classical conditioning
  • corticosterone
  • fear
  • spontaneously hypertensive rats
  • strain differences

ASJC Scopus subject areas

  • Neuroscience(all)

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