Strategies for targeting protein-protein interactions with synthetic agents

Research output: Contribution to journalReview articlepeer-review

Abstract

(Chemical Equation Presented) The development of small-molecule modulators of protein-protein interactions is a formidable goal, albeit one that possesses significant potential for the discovery of novel therapeutics. Despite the daunting challenges, a variety of examples exists for the inhibition of two large protein partners with low-molecular-weight ligands. This review discusses the strategies for targeting protein-protein interactions and the state of the art in the rational design of molecules that mimic the structures and functions of their natural targets.

Original languageEnglish (US)
Pages (from-to)4130-4163
Number of pages34
JournalAngewandte Chemie - International Edition
Volume44
Issue number27
DOIs
StatePublished - Jul 4 2005

Keywords

  • Inhibitors
  • Molecular recognition
  • Peptidomimetics
  • Protein-protein interactions
  • Rational design

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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