Structural basis of Hox specificity

David S. Wilson, Claude Desplan

Research output: Contribution to journalArticlepeer-review


On their own, the homeotic selector (Hox) transcriptional regulators bind very short, rather similar DNA sequences. To elevate their functional specificity, Hox proteins heterodimerize with other homeodomain-containing proteins. The structural basis for this fruitful partnership is now coming into view.

Original languageEnglish (US)
Pages (from-to)297-300
Number of pages4
JournalNature Structural Biology
Issue number4
StatePublished - 1999

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Genetics


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