Structural DNA nanotechnology: Molecular construction and computation

Ruojie Sha, Xiaoping Zhang, Shiping Liao, Pamela E. Constantinou, Baoquan Ding, Tong Wang, Alejandra V. Garibotti, Hong Zhong, Lisa B. Israel, Xing Wang, Gang Wu, Banani Chakraborty, Junghuei Chen, Yuwen Zhang, Hao Yan, Zhiyong Shen, Wanqiu Shen, Phiset Sa-Ardyen, Jens Kopatsch, Jiwen ZhengPhilip S. Lukeman, William B. Sherman, Chengde Mao, Natasha Jonoska, Nadrian C. Seeman

Research output: Contribution to journalConference articlepeer-review


Structural DNA nanotechnology entails the construction of objects, lattices and devices from branched DNA molecules. Branched DNA molecules open the way for the construction of a variety of N-connected motifs. These motifs can be joined by cohesive interactions to produce larger constructs in a bottom-up approach to nanoconstruction. The first objects produced by this approach were stick polyhedra and topological targets, such as knots and Borromean rings. These were followed by periodic arrays with programmable patterns. It is possible to exploit DNA structural transitions and sequence-specific binding to produce a variety of DNA nanomechanical devices, which include a bipedal walker and a machine that emulates the translational capabilities of the ribosome. Much of the promise of this methodology involves the use of DNA to scaffold other materials, such as biological macromolecules, nanoelectronic components, and polymers. These systems are designed to lead to improvements in crystallography, computation and the production of diverse and exotic materials. Branched DNA can be used to emulate Wang tiles, and it can be used to construct arbitrary irregular graphs and to address their colorability.

Original languageEnglish (US)
Pages (from-to)20-31
Number of pages12
JournalLecture Notes in Computer Science
StatePublished - 2005
Event4th International Conference on Unconventional Computation, UC 2005 - Sevilla, Spain
Duration: Oct 3 2005Oct 7 2005


  • Bottom-Up Nanoscale Construction
  • DNA Sequence Design
  • Nanorobotics
  • Nanoscale DNA Objects
  • Nanoscale Pattern Design
  • Unusual DNA Motifs

ASJC Scopus subject areas

  • Theoretical Computer Science
  • General Computer Science


Dive into the research topics of 'Structural DNA nanotechnology: Molecular construction and computation'. Together they form a unique fingerprint.

Cite this