Structural elucidation of the neuraminidase inhibitor zanamivir (relenza): Creeping and diffusion for polymorph separation

Naba K. Nath, Nobuhiro Yasuda, Wael M. Rabeh, Subash Chandra Sahoo, Panče Naumov

Research output: Contribution to journalArticlepeer-review

Abstract

Zanamivir, the active ingredient of the antiviral drug Relenza, is the most potent of the four currently approved neuraminidase inhibitors for treatment of pandemic strains of influenza. A combination of solution creeping and vapor diffusion of antisolvent was successfully applied to obtain two crystalline polymorphic dihydrates and to accomplish the first structure determination of zanamivir with X-ray diffraction.

Original languageEnglish (US)
Pages (from-to)770-774
Number of pages5
JournalCrystal Growth and Design
Volume14
Issue number2
DOIs
StatePublished - Feb 5 2014

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

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